Conus venom peptide pharmacology
Conopeptides are a diverse group of recently evolved venom peptides used for prey capture
and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with …
and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with …
Marine natural products
Covering: 2005. Previous review: Nat. Prod. Rep., 2006, 23, 26 This review covers the
literature published in 2005 for marine natural products, with 704 citations (493 for the …
literature published in 2005 for marine natural products, with 704 citations (493 for the …
Sodium channel inactivation: molecular determinants and modulation
W Ulbricht - Physiological reviews, 2005 - journals.physiology.org
Voltage-gated sodium channels open (activate) when the membrane is depolarized and
close on repolarization (deactivate) but also on continuing depolarization by a process …
close on repolarization (deactivate) but also on continuing depolarization by a process …
Marine pharmacology in 2003–4: Marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet …
AMS Mayer, AD Rodríguez, RGS Berlinck… - … and Physiology Part C …, 2007 - Elsevier
The current marine pharmacology review that covers the peer-reviewed literature during
2003 and 2004 is a sequel to the authors' 1998–2002 reviews, and highlights the preclinical …
2003 and 2004 is a sequel to the authors' 1998–2002 reviews, and highlights the preclinical …
Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks
V Lavergne, I Harliwong, A Jones… - Proceedings of the …, 2015 - National Acad Sciences
Cone snails are predatory marine gastropods characterized by a sophisticated venom
apparatus responsible for the biosynthesis and delivery of complex mixtures of cysteine-rich …
apparatus responsible for the biosynthesis and delivery of complex mixtures of cysteine-rich …
Animal toxins influence voltage-gated sodium channel function
J Gilchrist, BM Olivera, F Bosmans - Voltage Gated Sodium Channels, 2014 - Springer
Voltage-gated sodium (Nav) channels are essential contributors to neuronal excitability,
making them the most commonly targeted ion channel family by toxins found in animal …
making them the most commonly targeted ion channel family by toxins found in animal …
Conotoxins as research tools and drug leads
CJ Armishaw, PF Alewood - Current Protein and Peptide …, 2005 - ingentaconnect.com
The complex mixture of biologically active peptides that constitute the venom of Conus
species provides a rich source of ion channel neurotoxins. These peptides, commonly …
species provides a rich source of ion channel neurotoxins. These peptides, commonly …
Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics?
O Knapp, JR McArthur, DJ Adams - Toxins, 2012 - mdpi.com
Voltage-gated sodium channels (VGSC) are the primary mediators of electrical signal
amplification and propagation in excitable cells. VGSC subtypes are diverse, with different …
amplification and propagation in excitable cells. VGSC subtypes are diverse, with different …
Marine toxins that target voltage-gated sodium channels
Eukaryotic, voltage-gated sodium (NaV) channels are large membrane proteins which
underlie generation and propagation of rapid electrical signals in nerve, muscle and heart …
underlie generation and propagation of rapid electrical signals in nerve, muscle and heart …
Historical perspective of the characterization of conotoxins targeting voltage-gated sodium channels
JR Groome - Marine Drugs, 2023 - mdpi.com
Marine toxins have potent actions on diverse sodium ion channels regulated by
transmembrane voltage (voltage-gated ion channels) or by neurotransmitters (nicotinic …
transmembrane voltage (voltage-gated ion channels) or by neurotransmitters (nicotinic …