Dimeric drugs

A Nudelman - Current Medicinal Chemistry, 2022 - ingentaconnect.com
This review intends to summarize the structures of an extensive number of symmetrical-
dimeric drugs, having two monomers, linked via a bridging entity emphasizing the versatility …

Imidazo [1, 2-a] pyridine-based hybrids. Copper-catalyzed cycloaddition synthesis, photophysics, docking, and interaction studies with biomacromolecules

EF Lopes, MT Saraiva, NP Debia, L Silva, OA Chaves… - Dyes and …, 2023 - Elsevier
Herein, we report the connection between imidazo [1, 2-a] pyridines with several biologically
relevant molecules. The strategy used to build these connections was based on a copper …

Förster resonance energy transfer from Hoechst 33258 to SYBR Green I in cholesteric liquid-crystalline DNA

VN Morozov, MA Klimovich, AA Kostyukov… - Journal of …, 2022 - Elsevier
In the present work Förster resonance energy transfer (FRET) between DNA-specific
fluorescent dyes Hoechst 33258 (Ht58; donor) and SYBR Green I (SG; acceptor) is …

Photoactive homomolecular bis (n)-Lophine dyads: Multicomponent synthesis, photophysical properties, theoretical investigation, docking and interaction studies with …

VS Câmara, OA Chaves, BB de Araújo… - Journal of Molecular …, 2022 - Elsevier
This work reports the synthesis of four homomolecular bis (n)-Lophines dyads achieved by a
one-pot four component reaction. The dyads show absorption maxima below 300 nm and …

Impact of the aging of ultrasmall gold nanoparticles on their interaction with cholesteric DNA microparticles

MA Klimovich, MA Kolyvanova, OV Dement'eva… - Colloid Journal, 2023 - Springer
The correlation between the time of preliminary storage of ultrasmall gold nanoparticles
(GNPs) synthesized according to the Duff method and the structural aspects of their …

DNA Sequence-Specific Ligands. 19. Synthesis, Spectral Properties, Virological and Biochemical Studies of DB3(n) Fluorescent Dimeric Trisbenzimidazoles

AF Arutyunyan, AA Kostyukov, SP Korolev, MB Gottikh… - Molecular Biology, 2023 - Springer
In this work, we synthesized and characterized the properties of a series of new fluorescent
DB 3 (n) narrow-groove ligands. DB 3 (n) compounds based on dimeric trisbenzimidazoles …

О новом подходе к изучению и оценке эффективности ДНК-специфичных радиопротекторов

MА Колыванова, МА Колыванова… - Himiâ vysokih …, 2024 - journals.rcsi.science
Исследована принципиальная возможность использования способности молекул ДНК
низкой молекулярной массы образовывать оптически активные холестерические …

[PDF][PDF] Влияние старения ультрамалых наночастиц золота на их взаимодействие с холестерическими микрочастицами ДНК

ОВ Дементьева, ОН Климович, ВМ Рудой… - КОЛЛОИДНЫЙ …, 2023 - researchgate.net
Исследована корреляция между временем предварительной выдержки
синтезированных по методу Даффа ультрамалых наночастиц золота (НЧЗ) и …

On a Novel Approach to Investigation and Evaluation of the Efficacy of DNA-Binding Radioprotectors

MA Kolyvanova, NS Lifanovsky, EA Nikitin… - High Energy …, 2024 - Springer
A fundamental possibility of using the ability of low-molecular-weight DNA molecules to form
optically active cholesteric liquid-crystalline dispersions (CLCDs) to estimate the efficacy of …

[HTML][HTML] Dimeric Bis-Benzimidazole-Pyrroles DB2Py (n)–AT-Site-Specific Ligands: Synthesis, Physicochemical Analysis, and Biological Activity

OY Susova, SS Karshieva, AA Kostyukov… - Acta …, 2024 - ncbi.nlm.nih.gov
Its broad spectrum of biological activity makes benzimidazole a fundamental
pharmacophore in pharmaceutics. The paper describes newly synthesized AT-specific …