Modelling chromosome-wide target search
L Hedström, L Lizana - New Journal of Physics, 2023 - iopscience.iop.org
The most common gene regulation mechanism is when a transcription factor (TF) protein
binds to a regulatory sequence to increase or decrease RNA transcription. However, TFs …
binds to a regulatory sequence to increase or decrease RNA transcription. However, TFs …
Enhancer-Insulator Pairing Reveals Heterogeneous Dynamics in Long-Distance 3D Gene Regulation
Cells regulate fates and complex body plans using spatiotemporal signaling cascades that
alter gene expression. Short DNA sequences, known as enhancers (50–1500 base pairs) …
alter gene expression. Short DNA sequences, known as enhancers (50–1500 base pairs) …
[HTML][HTML] Conditional probability as found in nature: Facilitated diffusion
O Hachmo, A Amir - American Journal of Physics, 2023 - pubs.aip.org
Search processes are ubiquitous in physical and biological phenomena, often involving the
random motion of molecules. In particular, transcription factors (TFs) are proteins that …
random motion of molecules. In particular, transcription factors (TFs) are proteins that …
Target search in the CRISPR/Cas9 system: facilitated diffusion with target cues
Q Lu, S Pigolotti - New Journal of Physics, 2024 - iopscience.iop.org
We study how Cas9, a central component of the CRISPR/Cas9 system, searches for a target
sequence on the DNA. We propose a model that includes as key ingredients 3D diffusion …
sequence on the DNA. We propose a model that includes as key ingredients 3D diffusion …
Universal stability towards decoherence in quantum diffusive 1D chains
FS Lozano-Negro, EA Navarro, NC Chávez… - arXiv preprint arXiv …, 2023 - arxiv.org
Coherent diffusion usually arises between the localized and the ballistic regime, where
typically Metal-Insulator Transitions emerge. By studying three different paradigmatic …
typically Metal-Insulator Transitions emerge. By studying three different paradigmatic …