A large number of hormones, neurotransmitters, chemokines, local mediators, and sensory
stimuli exert their effects on cells and organisms by binding to G protein-coupled receptors …

This review is concerned with the structures and mechanisms of a superfamily of regulatory
GTP hydrolases (G proteins). G proteins include Ras and its close homologs, translation …

G-protein-coupled receptors comprise the largest family of mammalian transmembrane
receptors. They mediate numerous cellular pathways by coupling with downstream …

The structure of a heterotrimeric G protein reveals the mechanism of the nucleotide-
dependent engagement of the α and βγ subunits that regulates their interaction with receptor …

G protein–coupled receptors (GPCRs) relay diverse extracellular signals into cells by
catalyzing nucleotide release from heterotrimeric G proteins, but the mechanism underlying …

Both the α and βγ subunits of heterotrimeric guanine nucleotide–binding proteins (G
proteins) communicate signals from receptors to effectors. Gβγ subunits can regulate a …

1. Introduction 22. Heterotrimeric G-protein structure 32.1. G-protein α subunit 32.2. G-
protein βγ dimer 82.3. Unique role of Gβ5 in complexes with RGS proteins 92.4 …

Parkinson disease is a neurodegenerative disorder whose symptoms are caused by the loss
of dopaminergic neurons innervating the striatum. As striatal dopamine levels fall, striatal …

A multitude of heptahelical receptors use heterotrimeric G proteins to transduce signals to
specific effector target molecules. The G protein transducin, Gt, couples photon-activated …

G protein-coupled receptors (GPCRs) are a family of cell-surface proteins that play critical
roles in regulating a variety of pathophysiological processes and thus are targeted by almost …