The Rpd3L histone deacetylase (HDAC) complex is an ancient 12-subunit complex
conserved in a broad range of eukaryotes that performs localized deacetylation at or near …

Actin is a multi-functional protein that is involved in numerous cellular processes including
cytoskeleton regulation, cell migration, and cellular integrity. In these processes, actin's role …

Most factors that regulate gene transcription in eukaryotic cells are multimeric, often large,
protein complexes. The understanding of the biogenesis pathways of such large and …

Histones are subject to a diverse array of post-translational modifications. Among them,
lysine acetylation is not only the most pervasive and dynamic modification but also highly …

The human nucleosome acetyltransferase of histone H4 (NuA4)/Tat-interactive protein, 60
kilodalton (TIP60) coactivator complex, a fusion of the yeast switch/sucrose nonfermentable …

NuA4 is a highly conserved histone acetyltransferase complex that functions in transcription
and DNA repair. Four groups have recently determined the structure of NuA4 from two …

Histone lysine acetyltransferase MYST-associated NuA4 complex is conserved from yeast to
humans and plays key roles in cell cycle regulation, gene transcription, and DNA …

H2A. Z is a conserved histone variant that is localized to specific genomic regions where it
plays important roles in transcription, DNA repair, and replication. Central to the …

Résumé L'organisation des génomes eucaryotes sous forme de chromatine constitue un
élément de régulation essentiel de tous les processus cellulaires dépendants de l'ADN. Les …

The yeast lysine acetyltransferase complex NuA4 was initially described to target histone H4
for acetylation but since then many non-histone targets of NuA4 have been identified, a …