Unmet medical needs in chronic, non-communicable inflammatory skin diseases

H Ujiie, D Rosmarin, MP Schön, S Ständer… - Frontiers in …, 2022 - frontiersin.org
An estimated 20–25% of the population is affected by chronic, non-communicable
inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most …

Dermatomyositis: clinical features and pathogenesis

ME DeWane, R Waldman, J Lu - Journal of the American Academy of …, 2020 - Elsevier
Dermatomyositis (DM) is an idiopathic inflammatory myopathy that is clinically
heterogeneous and that can be difficult to diagnose. Cutaneous manifestations sometimes …

Dermatomyositis: an update on diagnosis and treatment

GA Cobos, A Femia, RA Vleugels - American Journal of Clinical …, 2020 - Springer
Dermatomyositis is a rare inflammatory disease with characteristic cutaneous findings and
varying amounts of systemic involvement. Patients may present with skin disease alone …

Cutaneous ulceration in dermatomyositis: association with anti–melanoma differentiation–associated gene 5 antibodies and interstitial lung disease

NS Narang, L Casciola‐Rosen, S Li… - Arthritis care & …, 2015 - Wiley Online Library
Objective To identify clinical and serologic correlates of cutaneous ulcers in dermatomyositis
(DM). Methods We retrospectively examined a cohort of 152 DM patients. We compared the …

Correlation of cutaneous disease activity with type 1 interferon gene signature and interferon β in dermatomyositis

C Huard, SV Gullà, DV Bennett, AJ Coyle… - British Journal of …, 2017 - academic.oup.com
Background Dermatomyositis (DM) is an autoimmune disease primarily affecting skin and
muscle. Objectives The purpose of this study was to determine whether an association exists …

Safety and efficacy of lenabasum, a cannabinoid receptor type 2 agonist, in patients with dermatomyositis with refractory skin disease: a randomized clinical trial

VP Werth, E Hejazi, SM Pena, J Haber, M Zeidi… - Journal of Investigative …, 2022 - Elsevier
Background Treatment options are limited for skin disease in dermatomyositis. Lenabasum
is a cannabinoid receptor type 2 agonist that triggers the resolution of inflammation …

Quality of life in adults with facial port-wine stains

SL Hagen, KR Grey, DZ Korta, KM Kelly - Journal of the American Academy …, 2017 - Elsevier
Background Facial port-wine stains (PWS) are considered by some an aesthetic skin
problem, yet impact on quality of life (QoL) has not been objectively documented. Objective …

Itch in dermatomyositis: the role of increased skin interleukin‐31

HJ Kim, M Zeidi, D Bonciani, SM Pena… - British Journal of …, 2018 - academic.oup.com
Summary Background Interleukin (IL)‐31 is implicated in pruritus associated with pruritic
skin diseases like atopic dermatitis. Although pruritus is a prominent feature in …

Validation of the Cutaneous Dermatomyositis Disease Area and Severity Index: characterizing disease severity and assessing responsiveness to clinical change

CO Anyanwu, DF Fiorentino, L Chung… - British Journal of …, 2015 - academic.oup.com
Summary Background The Cutaneous Dermatomyositis Disease Area and Severity Index
(CDASI) was developed for use in clinical trials and longitudinal patient assessment …

Cannabinoid type 2 receptor (CB2R) distribution in dermatomyositis skin and peripheral blood mononuclear cells (PBMCs) and in vivo effects of LenabasumTM

S Maddukuri, J Patel, DA Diaz, KL Chen… - Arthritis research & …, 2022 - Springer
Background Lenabasum is a cannabinoid type 2 receptor (CB2R) reverse agonist that
demonstrates anti-inflammatory effects in vivo and in vitro in dermatomyositis (DM) and is …