Research progress in oxygen carrier design and application

Q Ye, D Zheng, K Chen, J Wu - Molecular Pharmaceutics, 2023 - ACS Publications
Ischemia or hypoxia can lead to pathological changes in the metabolism and function of
tissues and then lead to various diseases. Timely and effective blood resuscitation or …

[HTML][HTML] A novel PEG-mediated approach to entrap hemoglobin (Hb) within ZIF-8 nanoparticles: Balancing crystalline structure, Hb content and functionality

C Coll-Satue, M Rubio-Huertas, A Ducrot… - Biomaterials …, 2024 - Elsevier
Hemoglobin (Hb)-based oxygen carriers are investigated as a potential alternative or
supplement to regular blood transfusions, particularly in critical and life-threatening …

Hemoglobin-loaded ZIF-8 Nanoparticles Equipped with PEGylated Metal-phenolic Network Coatings: An Oxygen Carrier with Antioxidant and Stealth Properties

C Coll-Satue, E Cabrera-San Millan… - Journal of Materials …, 2025 - pubs.rsc.org
Hemoglobin-based oxygen carriers (HBOCs) offer a promising alternative to conventional
blood transfusions in emergency scenarios. However, achieving optimal stability …

Ag nanoparticles on MXene nanosheets for combined ionic and photothermal therapy of bacterial infections

W Zhou, J Chen, T Liao, Q Wu, N Guo… - ACS Applied Nano …, 2024 - ACS Publications
In view of the increasing bacterial resistance, 2D MXenes are promising alternatives to
antibiotics. However, MXene-based photothermal therapy (PTT) suffers from unsatisfactory …

[HTML][HTML] Comparative evaluation of UV-Vis spectroscopy-based approaches for hemoglobin quantification: method selection and practical insights

C Coll-Satue, MMT Jansman, L Hosta-Rigau - Biomolecules, 2024 - mdpi.com
The growing demand for effective alternatives to red blood cells (RBCs) has spurred
significant research into hemoglobin (Hb)-based oxygen carriers (HBOCs). Accurate …

Metal–organic framework-based oxygen carriers with antioxidant activity resulting from the incorporation of gold nanozymes

X Liu, NP Domingues, E Oveisi, C Coll-Satue… - Biomaterials …, 2023 - pubs.rsc.org
Blood transfusions are a life-saving procedure since they can preserve the body's oxygen
levels in patients suffering from acute trauma, undergoing surgery, receiving chemotherapy …

In vitro and in vivo investigations of hemoglobin-loaded PEGylated ZIF-8 nanoparticles as oxygen carriers for emergency transfusion

G Bor, W Jin, D Douka, NJ Borthwick, X Liu… - Biomaterials …, 2025 - Elsevier
The limitations of traditional blood supply systems, particularly where ideal storage is
unfeasible, challenge the efficacy of transfusion medicine, especially in emergencies and …

Optimization and Investigation of Hemoglobin‐Loaded ZIF‐90 Metal–Organic Framework Nanoparticles as Artificial Oxygen Carriers

D Douka, W Jin, C Cantallops‐Iglesias… - Particle & Particle …, 2024 - Wiley Online Library
Blood transfusions are vital, yet limited shelf‐life and storage conditions of red blood cells
(RBCs) hinder their use in emergencies. Hemoglobin‐based oxygen carriers (HBOCs) aim …

Synthesis of bioactive hemoglobin-based oxygen carrier nanoparticles via metal-phenolic complexation

M Nadimifar, W Jin, C Coll-Satue, G Bor… - Biomaterials …, 2024 - Elsevier
The transfusion of donor red blood cells (RBCs) is seriously hampered by important
drawbacks that include limited availability and portability, the requirement of being stored in …

A novel blood spot with oil sealing for antioxidation and completeness preservation of erythrocytes and hemoglobin

G Zha, X Xiao, Y Tian, H Zhu, Q Zhang, C Yu, H Li… - Analytica Chimica …, 2025 - Elsevier
Hemoglobin, the primary oxygen transport protein found in red blood cells (RBCs), plays a
critical role in both biomedical research and clinical diagnosis [1]. The investigation of …