Microglia shape the synaptic environment in health and disease, but synapses do not exist
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …

A structural scaffold embedding brain cells and vasculature is known as extracellular matrix
(ECM). The physical appearance of ECM in the central nervous system (CNS) ranges from a …

Extracellular matrix (ECM) molecules in the central nervous system form highly organized
ECM structures around cell somata, axon initial segments, and synapses and play …

Cortical plasticity is most evident during a critical period in early life, but the mechanisms that
restrict plasticity after the critical period are poorly understood. We found that a …

Accumulating data support the importance of interactions between pre-and postsynaptic
neuronal elements with astroglial processes and extracellular matrix (ECM) for formation …

Chondroitin sulfate proteoglycans (CSPGs) consist of a core protein and glycosaminoglycan
(GAG) chains. There is enormous structural diversity among CSPGs due to variation in the …

The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin
sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins …

A hypothesis and the experiments to test it propose that very long-term memories, such as
fear conditioning, are stored as the pattern of holes in the perineuronal net (PNN), a …

We developed a method to extract differentially chondroitin sulfate proteoglycans (CSPGs)
that are diffusely present in the central nervous system (CNS) matrix and CSPGs that are …

Perineuronal nets (PNNs) are specialized complexes of extracellular matrix molecules that
surround the somata of fast-spiking neurons throughout the vertebrate brain. PNNs are …