Spotlight on the impact of viral infections on Hematopoietic Stem Cells (HSCs) with a focus on COVID-19 effects

K Nasiri, S Mohammadzadehsaliani… - Cell Communication and …, 2023 - Springer
Hematopoietic stem cells (HSCs) are known for their significant capability to reconstitute and
preserve a functional hematopoietic system in long-term periods after transplantation into …

Viral infections in HSCT: detection, monitoring, clinical management, and immunologic implications

C Annaloro, F Serpenti, G Saporiti, G Galassi… - Frontiers in …, 2021 - frontiersin.org
In spite of an increasing array of investigations, the relationships between viral infections
and allogeneic hematopoietic stem cell transplantation (HSCT) are still controversial, and …

Posttransplant cyclophosphamide is associated with increased cytomegalovirus infection: a CIBMTR analysis

SR Goldsmith, MB Abid, JJ Auletta… - Blood, The Journal …, 2021 - ashpublications.org
Prior studies suggest increased cytomegalovirus (CMV) infection after haploidentical donor
transplantation with posttransplant cyclophosphamide (HaploCy). The role of allograft …

Bright and early: Inhibiting human cytomegalovirus by targeting major immediate-early gene expression or protein function

CS Adamson, MM Nevels - Viruses, 2020 - mdpi.com
The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes
lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections …

The complex biology of human cytomegalovirus latency

F Goodrum - Advances in virus research, 2022 - Elsevier
While many viral infections are limited and eventually resolved by the host immune
response or by death of the host, other viruses establish long-term relationships with the …

Different routes of MHC-I delivery to phagosomes and their consequences to CD8 T cell immunity

JM Blander - Seminars in immunology, 2023 - Elsevier
Dendritic cells (DCs) present internalized antigens to CD8 T cells through cross-
presentation by major histocompatibility complex class I (MHC-I) molecules. While …

Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation

L Stern, HM McGuire, S Avdic… - Nature …, 2022 - nature.com
Human cytomegalovirus reactivation is a major opportunistic infection after allogeneic
haematopoietic stem cell transplantation and has a complex relationship with post …

The differentiation of human cytomegalovirus infected-monocytes is required for viral replication

CK Min, AK Shakya, BJ Lee, DN Streblow… - Frontiers in Cellular …, 2020 - frontiersin.org
Viral dissemination is a key mechanism responsible for persistence and disease following
human cytomegalovirus (HCMV) infection. Monocytes play a pivotal role in viral …

Bispecific antibody therapy, its use and risks for infection: Bridging the knowledge gap

AP Longhitano, MA Slavin, SJ Harrison, BW Teh - Blood reviews, 2021 - Elsevier
Relapsed haematological malignancies have a poor disease prognosis with current
therapies. Bispecific antibodies (BsAbs) are becoming increasingly recognised for their …

H84T BanLec has broad spectrum antiviral activity against human herpesviruses in cells, skin, and mice

MG Lloyd, D Liu, M Legendre, DM Markovitz… - Scientific Reports, 2022 - nature.com
H84T BanLec is a molecularly engineered lectin cloned from bananas with broad-spectrum
antiviral activity against several RNA viruses. H84T BanLec dimers bind glycoproteins …