The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …

Bioluminescence is the fascinating natural phenomenon by which living creatures produce
light. Bioluminescence occurs when the oxidation of a small-molecule luciferin is catalysed …

Tirzepatide (LY3298176) is a dual GIP and GLP-1 receptor agonist under development for
the treatment of type 2 diabetes mellitus (T2DM), obesity, and nonalcoholic steatohepatitis …

The reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the
efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of …

Summary The CDK4/6 inhibitor, palbociclib (PAL), significantly improves progression-free
survival in HR+/HER2− breast cancer when combined with anti-hormonals. We sought to …

Antisense oligonucleotides (ASOs) modified with phosphorothioate (PS) linkages and
different 2′ modifications can be used either as drugs (eg, to treat homozygous familial …

The biomedical field has greatly benefited from the discovery of bioluminescent proteins.
Currently, scientists employ bioluminescent systems for numerous biomedical applications …

Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due
to their role in disease, notably cancer. Since their discovery, several mechanisms of RTK …

Intracellular signaling pathways are mediated by changes in protein abundance and post-
translational modifications. A common approach for investigating signaling mechanisms and …

Tirzepatide (LY3298176) is a fatty-acid-modified, dual incretin receptor agonist that exhibits
pharmacology similar to native GIP at the glucose-dependent insulinotropic polypeptide …