Advances in improvement strategies of digital nucleic acid amplification for pathogen detection

X Xiang, Y Shang, J Zhang, Y Ding, Q Wu - TrAC Trends in Analytical …, 2022 - Elsevier
Digital nucleic acid amplification technologies (dNAATs) have become an emerging platform
for pathogen detection. It is not only suitable for the absolute quantitative analysis of target …

Reverse transcription-free digital-quantitative-PCR for microRNA analysis

HT Mai, BC Vanness, TH Linz - Analyst, 2023 - pubs.rsc.org
MicroRNAs (miRNAs) are non-coding RNA sequences that regulate many biological
processes and have become central targets of biomedical research. However, their naturally …

Microfluidic digital quantitative PCR to measure internal cargo of individual liposomes

BF McCarthy Riley, HT Mai, TH Linz - Analytical Chemistry, 2022 - ACS Publications
Lipid nanoparticles serve as drug delivery vehicles for biopharmaceutical products. The lipid
membrane shields internal nucleic-acid drug cargo from enzymatic degradation and …

Multiplexed miRNA and Protein Analysis Using Digital Quantitative PCR in Microwell Arrays

BC Vanness, TH Linz - Analytical Chemistry, 2024 - ACS Publications
Proteins and microRNAs (miRNAs) act in tandem within biological pathways to regulate
cellular functions, and their misregulation has been correlated to numerous diseases …