[HTML][HTML] Simulation-based approaches for drug delivery systems: Navigating advancements, opportunities, and challenges

I Salahshoori, M Golriz, MAL Nobre, S Mahdavi… - Journal of Molecular …, 2024 - Elsevier
Efficient drug delivery systems (DDSs) play a pivotal role in ensuring pharmaceuticals'
targeted and effective administration. However, the intricate interplay between drug …

A review on the development of bacterial multi-epitope recombinant protein vaccines via reverse vaccinology

Y Li, MHR Farhan, X Yang, Y Guo, Y Sui, J Chu… - International Journal of …, 2024 - Elsevier
Bacterial vaccines play a crucial role in combating bacterial infectious diseases. Apart from
the prevention of disease, bacterial vaccines also help to reduce the mortality rates in …

Immunoinformatics, molecular docking and dynamics simulation approaches unveil a multi epitope-based potent peptide vaccine candidate against avian leukosis …

SO Elshafei, NA Mahmoud, YA Almofti - Scientific Reports, 2024 - nature.com
Lymphoid leukosis is a poultry neoplastic disease caused by avian leukosis virus (ALV) and
is characterized by high morbidity and variable mortality rates in chicks. Currently, no …

Cancer nanovaccines: nanomaterials and clinical perspectives

N Desai, V Chavda, TRR Singh, ND Thorat, LK Vora - Small, 2024 - Wiley Online Library
Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing
nanotechnology to augment traditional vaccine efficacy. This review comprehensively …

Exploring Monkeypox: Prospects for therapeutics through computational-aided drug discovery

DB Grajales, S Kar - Molecular Diversity, 2023 - Springer
Monkeypox virus (MPXV) has emerged as a significant public health concern due to its
potential for human transmission and its severe clinical manifestations. This review …

Fragments of local symmetry in a sequence of amino acids: Does one can use for QSPR/QSAR of peptides?

AP Toropova, AA Toropov, P Kumar, A Kumar… - Journal of Molecular …, 2023 - Elsevier
Most of the protein interactions rely on small domains binding to short peptides. However,
neither the number of potential interactions mediated by each domain nor the degree of …

Advancing vaccine development against Opisthorchis viverrini: A synergistic integration of omics technologies and advanced computational tools

A Kafle, SC Ojha - Frontiers in Pharmacology, 2024 - frontiersin.org
The liver fluke O. viverrini (Opisthorchis viverrini), a neglected tropical disease (NTD),
endemic to the Great Mekong Subregion (GMS), mainly afflicts the northeastern region of …

[HTML][HTML] Immunoinformatics-aided rational design of multiepitope-based peptide vaccine (MEBV) targeting human parainfluenza virus 3 (HPIV-3) stable proteins

MS Hossen, MN Hasan, M Haque, T Al Arian… - Journal of Genetic …, 2023 - Elsevier
Abstract Background Human parainfluenza viruses (HPIVs) are common RNA viruses
responsible for respiratory tract infections. Human parainfluenza virus 3 (HPIV-3) is …

In silico design and analysis of a multiepitope vaccine against Chlamydia

T Tanner, FNU Medhavi, S Richardson… - Pathogens and …, 2024 - academic.oup.com
Chlamydia trachomatis (Ct) is the most common sexually transmitted bacterial infection
worldwide, potentially leading to severe pathologies including pelvic inflammatory disease …

Design of multi-epitope vaccine candidate based on OmpA, CarO and ZnuD proteins against multi-drug resistant Acinetobacter baumannii

B Negahdari, P Sarkoohi, B Shahbazi, K Ahmadi - Heliyon, 2024 - cell.com
Acinetobacter baumannii has been identified as a major cause of nosocomial infections.
Acinetobacter infections are often difficult to treat with multidrug resistant phenotypes. One of …