In five large‐scale trials involving> 40 000 patients, sodium–glucose cotransporter 2
(SGLT2) inhibitors decreased the risk of serious heart failure events by 25–40%. This effect …

Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) were initially recommended as oral
anti-diabetic drugs to treat type 2 diabetes (T2D), by inhibiting SGLT2 in proximal tubule and …

The natriuretic peptide family (NPs) is a group of natural endocrine hormones, containing a
17-amino acid ring structure connected by disulfide bonds of two cysteines. In this review …

Reactive cardiac hypertrophy (CH) is an increase in heart mass in response to
hemodynamic overload. Exercise-induced CH emerges as an adaptive response with …

The mammalian Na+/H+ exchanger isoform one (NHE1) is a plasma membrane protein that
is ubiquitously present in human cells. It functions to regulate intracellular pH removing an …

Renal cell carcinoma, an aggressive malignancy, is often incidentally diagnosed. The
patient remains asymptomatic to the late stage of the disease, when the local or distant …

Approximately 5 million individuals in the US are living with congestive heart failure (CHF),
with 650,000 new cases being diagnosed every year. CHF has a multifactorial etiology …

The mammalian Na+/H+ exchanger (NHE) is a family of ubiquitous membrane proteins
present in humans. Isoform one (NHE1) is present on the plasma membrane and regulates …

The cardiac Na+/H+ exchanger (NHE1) is a membrane glycoprotein fundamental for proper
cell functioning due its multiple housekeeping tasks, including regulation of intracellular pH …

Background/Aims: Vasopressin is a powerful stimulator of vascular calcification, augmenting
osteogenic signaling in vascular smooth muscle cells (VSMCs) including upregulation of …