Targeting orexin receptors for the treatment of insomnia: from physiological mechanisms to current clinical evidence and recommendations
MP Mogavero, A Silvani, G Lanza… - Nature and science of …, 2023 - Taylor & Francis
After a detailed description of orexins and their roles in sleep and other medical disorders,
we discuss here the current clinical evidence on the effects of dual (DORAs) or selective …
we discuss here the current clinical evidence on the effects of dual (DORAs) or selective …
International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology
The orexin system consists of the peptide transmitters orexin-A and-B and the G protein-
coupled orexin receptors OX 1 and OX 2. Orexin receptors are capable of coupling to all four …
coupled orexin receptors OX 1 and OX 2. Orexin receptors are capable of coupling to all four …
[HTML][HTML] Orexin neurons play contrasting roles in itch and pain neural processing via projecting to the periaqueductal gray
T Kaneko, A Oura, Y Imai, I Kusumoto-Yoshida… - Communications …, 2024 - nature.com
Pain and itch are recognized as antagonistically regulated sensations; pain suppresses itch,
whilst pain inhibition enhances itch. The neural mechanisms at the central nervous system …
whilst pain inhibition enhances itch. The neural mechanisms at the central nervous system …
[HTML][HTML] Contribution of activating lateral hypothalamus-lateral habenula circuit to nerve trauma-induced neuropathic pain in mice
HW Gu, GF Zhang, PM Liu, WT Pan, YX Tao… - Neurobiology of …, 2023 - Elsevier
Neuropathic pain, a severe clinical symptom, significantly affects the quality of life in the
patients. The molecular mechanisms underlying neuropathic pain have been the focus of …
patients. The molecular mechanisms underlying neuropathic pain have been the focus of …
The opposite roles of orexin neurons in pain and itch neural processing
T Kaneko, T Kuwaki - Peptides, 2023 - Elsevier
Pain and itch are antagonistically regulated sensations; pain suppresses itch, and inhibition
of pain enhances itch. Understanding the central neural circuit of antagonistic regulation …
of pain enhances itch. Understanding the central neural circuit of antagonistic regulation …
[HTML][HTML] Identification of hypothermia-inducing neurons in the preoptic area and activation of them by isoflurane anesthesia and central injection of adenosine
E Uchino, I Kusumoto-Yoshida, H Kashiwadani… - The Journal of …, 2024 - Springer
Hibernation and torpor are not passive responses caused by external temperature drops
and fasting but are active brain functions that lower body temperature. A population of …
and fasting but are active brain functions that lower body temperature. A population of …
[HTML][HTML] Contribution of Central and Peripheral Glial Cells in the Development and Persistence of Itch: Therapeutic Implication of Glial Modulation
P Gazerani - Neuroglia, 2023 - mdpi.com
Chronic itch (CI) is an unpleasant skin sensation accompanied by an intense scratching
desire that lasts 6 weeks or longer. Despite the high prevalence and negative impact on …
desire that lasts 6 weeks or longer. Despite the high prevalence and negative impact on …
The opposing roles of hypothalamic orexin neurons in pain and itch neural regulation
T Kaneko - The Autonomic Nervous System, 2023 - jstage.jst.go.jp
抄録 痛みと痒みは互いに相反する感覚として知られているが, 中枢神経系における痛みと痒みの
相互作用における神経機構についてはまだあまり分かっていない. 我々は視床下部に存在する …
相互作用における神経機構についてはまだあまり分かっていない. 我々は視床下部に存在する …
[PDF][PDF] Orexinergic System and Antinociception
E Özdemir - Current Researches in Health Sciences-II, 2023 - avesis.ebyu.edu.tr
Orexin-A and orexin-B neuropeptides are specifically synthesized and secreted in
hypothalamic neurons. It is known that the orexinergic system participates in pain …
hypothalamic neurons. It is known that the orexinergic system participates in pain …