Age-related macular degeneration (AMD) is the leading cause of visual impairment in the
aging population with limited understanding of its pathogenesis and a lack of effective …

Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant
mitochondria. Accumulating evidence implicates elimination of dysfunctional mitochondria …

Over the past decade, numerous advances have been made in the role and regulation of
inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises …

Autophagy is a genetically well-controlled cellular process that is tightly controlled by a set of
core genes, including the family of autophagy-related genes (ATG). Autophagy is a “double …

Autophagy has broad functions in immunity, ranging from cell-autonomous defence to
coordination of complex multicellular immune responses. The successful resolution of …

The cellular degradative pathway of autophagy has a fundamental role in immunity. Here,
we review the function of autophagy and autophagy proteins in inflammation. We discuss …

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

A common bottleneck in any drug development process is finding sufficiently accurate
models that capture key aspects of disease development and progression. Conventional …

Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite
the introduction of safer acellular pertussis vaccines (Pa). One explanation for this is that Pa …