Balanced general anesthesia, the most common management strategy used in anesthesia
care, entails the administration of different drugs together to create the anesthetic state …

Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Abstract Purpose of Review Our goal is to examine the processes—both central and
peripheral—that underlie the development of peripherally-induced neuropathic pain (pNP) …

Background: Emotional disorders are common comorbid affectations that exacerbate the
severity and persistence of chronic pain. Specifically, depressive symptoms can lead to an …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect
experienced by cancer patients receiving treatment with paclitaxel. The voltage-gated …

The activity of voltage-gated sodium channels has long been linked to disorders of neuronal
excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded …

Persistent pain disorders are usually not adequately alleviated by nonsteroidal anti‐
inflammatory drugs or other simple analgesics. Use of antidepressants as adjuvant therapy …

Voltage-gated sodium channels (VGSCs) are the basic ion channels for neuronal
excitability, which are crucial for the resting potential and the generation and propagation of …

Neuropathic pain is a disease of global burden. Its symptoms include spontaneous and
stimulus-evoked painful sensations. Several maladaptive mechanisms underlying these …

The gene SCN9A is responsible for three human pain disorders. Nonsense mutations cause
a complete absence of pain, whereas activating mutations cause severe episodic pain in …