Gastrointestinal (GI) cancers are highly heterogeneous at multiple levels. Tumor
heterogeneity can be captured by molecular profiling, such as genetic, epigenetic …

Numerous studies have shown that circRNAs are aberrantly expressed in various cancers
and play a significant role in tumor progression. However, the molecular mechanisms of …

Colorectal cancer (CRC) is a molecularly heterogeneous disease arising from gradual
accumulation of genetic and epigenetic changes. In the last decade, great efforts have been …

Breast cancer (BC) is the most frequently diagnosed malignancy in the world. Accumulating
evidence has indicated that circular RNAs (circRNAs) play essential roles in BC. Here we …

Simple Summary Colorectal cancer is a heterogeneous disease. Several efforts have been
made to characterize this heterogeneity but they have no impact in the clinic. In this work, we …

Lynch syndrome (LS) is the most common autosomal dominant cancer syndrome and is
characterized by high genetic cancer risk modified by lifestyle factors. This study explored …

Simple Summary Colorectal cancer is one of the most significant causes of cancer mortality
worldwide. Patients stratification is central to improve clinical practice and the Consensus …

Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease that is associated with
poor prognosis. Recent works have revealed the significant roles of miRNA in ccRCC …

The integration of machine learning (ML) techniques in colorectal cancer research and
healthcare has exhibited substantial potential to enhance detection, diagnosis, prognosis …

Lynch syndrome (LS) is the most common hereditary cancer syndrome. This thesis explored
the associations between circulating microRNAs (c-miRs), lifestyle habits, and the incidence …