▪ Abstract Hemagglutinin (HA) is the receptor-binding and membrane fusion glycoprotein of
influenza virus and the target for infectivity-neutralizing antibodies. The structures of three …

Antimicrobial peptides encompass a wide variety of structural motifs. Many peptides have α-
helical structures. The majority of these peptides are cationic and amphipathic but there are …

▪ Abstract Membrane fusion involves the merger of two phospholipid bilayers in an aqueous
environment. In artificial lipid bilayers, fusion proceeds by means of defined transition states …

Antimicrobial peptides (AMPs) have received considerable interest as a source of new
antibiotics with the potential for treatment of multiple-drug resistant infections. An important …

The N-terminal domain of the influenza hemagglutinin (HA) is the only portion of the
molecule that inserts deeply into membranes of infected cells to mediate the viral and the …

The 18.5 kDa isoform of myelin basic protein (MBP) is a major component of the myelin
sheath in the central nervous system of higher vertebrates, and a member of a larger family …

Site-directed spin labeling (SDSL) electron paramagnetic resonance (EPR) spectroscopy
has emerged as a well-established method that can provide specific information on the …

SNAREs are essential for intracellular membrane fusion. Using EPR, we determined the
structure of the transmembrane domain (TMD) of the vesicle (v)-SNARE Snc2p involved in …

Glycosylphosphatidylinositol-anchored influenza hemagglutinin (GPI-HA) mediates
hemifusion, whereas chimeras with foreign transmembrane (TM) domains mediate full …

A new empirical approach to model the solvent effects in protein− membrane complexes is
proposed. The generalized Born (GB) approximation is extended by including an implicit …