The maintenance of a healthy and functional mitochondrial network is critical during
development as well as throughout life in the response to physiological adaptations and …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

The eye lens of vertebrates is composed of fibre cells in which all membrane-bound
organelles undergo degradation during terminal differentiation to form an organelle-free …

Mitophagy is a conserved intracellular catabolic process responsible for the selective
removal of dysfunctional or superfluous mitochondria to maintain mitochondrial quality and …

Mitochondria are highly dynamic organelles and their proper function is crucial for the
maintenance of cellular homeostasis. Mitochondrial biogenesis and mitophagy are two …

Autophagy is a catabolic pathway that promotes the degradation and recycling of cellular
components. Proteins, lipids, and even whole organelles are engulfed in autophagosomes …

Autophagy is an evolutionarily conserved pathway that transports cytoplasmic components
for degradation into lysosomes. Selective autophagy can capture physically large objects …

The ocular lens is a model system for understanding important aspects of embryonic
development, such as cell specification and the spatiotemporally controlled formation of a …

Cataract, the clinical correlate of opacity or light scattering in the eye lens, is usually caused
by the presence of high-molecular-weight (HMW) protein aggregates or disruption of the …

Aging is a complex process that features a functional decline in many organelles. Various
factors influence the aging process, such as chromosomal abnormalities, epigenetic …