Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

The tricarboxylic acid (TCA) cycle is a central route for oxidative phosphorylation in cells,
and fulfills their bioenergetic, biosynthetic, and redox balance requirements. Despite early …

It has been long recognized that cancer cells reprogram their metabolism under hypoxia
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …

Glioblastoma (GBM) is the most common and aggressive primary brain tumor and is nearly
universally fatal. Targeted therapy and immunotherapy have had limited success in GBM …

Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell
lung cancer (NSCLC) being the predominant histological subtype. Despite the emergence of …

Kidney cancer is a cancer with an increasing incidence in recent years. Clear cell renal cell
carcinoma (ccRCC) accounts for up to 80% of all kidney cancers. The understanding of the …

A fundamental metabolic feature of cancerous tissues is high glucose consumption. The rate
of glucose consumption in a cancer cell can be 10–15 times higher than in normal cells …

Significance: Cancer cells are stabilized in an undifferentiated state similar to stem cells.
This leads to profound modifications of their metabolism, which further modifies their …

The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing globally. NAFLD
includes non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). NASH is …

Oral cavity squamous cell carcinoma (OCC) and oropharyngeal squamous cell carcinoma
(OPC) are among the most common cancers worldwide and are associated with high …