Axons are generally considered as reliable transmission cables in which stable propagation
occurs once an action potential is generated. Axon dysfunction occupies a central position in …

Voltage-gated sodium channels (VGSCs) are key mediators of intrinsic neuronal and muscle
excitability. Abnormal VGSC activity is central to the pathophysiology of epileptic seizures …

Endocannabinoids (eCBs) exert major control over neuronal activity by activating
cannabinoid receptors (CBRs). The functionality of the eCB system is primarily ascribed to …

Cannabis sativa contains many related compounds known as phytocannabinoids. The main
psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and …

Ion channels are crucial in the generation and modulation of excitability in the nervous
system and have been implicated in human epilepsy. Forty-one epilepsy-associated ion …

The human sodium channel family includes seven neuronal channels that are essential for
the initiation and propagation of action potentials in the CNS and PNS. In view of their critical …

Voltage-gated sodium channel blockers are one of the vital targets for the management of
several central nervous system diseases, including epilepsy, chronic pain, psychiatric …

Rare de novo mutations of sodium channels are thought to be an important cause of
sporadic epilepsy. The well established role of de novo mutations of sodium channel …

Voltage-gated sodium channel (VGSC) mutations cause severe epilepsies marked by
intermittent, pathological hypersynchronous brain states. Here we present two mechanisms …

During epileptogenesis a series of molecular and cellular events occur, culminating in an
increase in neuronal excitability, leading to seizure initiation. The entorhinal cortex has been …