Persons with schizophrenia exhibit sensitivity to stress and negative affect (NA), both
strongly correlated with poor functional outcome. This theoretical review suggests that NA …

Cognitive dysfunction in schizophrenia is one of the most pervasive and debilitating aspects
of the disorder. Among the numerous neural abnormalities that may contribute to …

Chronic adolescent marijuana use has been linked to the later development of psychiatric
diseases such as schizophrenia. GABAergic hypofunction in the prefrontal cortex (PFC) is a …

Background: Dysfunction in prefrontal cortex (PFC) GABA transmission has been proposed
to contribute to cognitive dysfunction in schizophrenia, yet how this system regulates …

Fear can potently inhibit ongoing behavior, including reward-seeking, yet the neural circuits
that underlie such suppression remain to be clarified. Prior studies have demonstrated that …

The flexible implementation of active and passive strategies to avoid danger is critical to
survival. Conversely, the inappropriate allocation of these behaviors may underlie …

A variety of stressful experiences can influence the ability to form and subsequently inhibit
fear memory. While nonsocial stress can impact fear learning and memory throughout the …

The notion that schizophrenia is a neurodevelopmental disorder in which neuropathologies
evolve gradually over the developmental course indicates a potential therapeutic window …

Clinical and pre-clinical evidence demonstrates divergent psychotropic effects of THC vs.
CBD. While THC can induce perceptual distortions and anxiogenic effects, CBD displays …

The prefrontal cortex (PFC) is critical for higher-order cognitive functions, including decision-
making. In psychiatric conditions such as schizophrenia, prefrontal dysfunction co-occurs …