Extracellular vesicles, tunneling nanotubes, and cellular interplay: synergies and missing links

M Nawaz, F Fatima - Frontiers in molecular biosciences, 2017 - frontiersin.org
The process of intercellular communication seems to have been a highly conserved
evolutionary process. Higher eukaryotes use several means of intercellular communication …

[HTML][HTML] Understanding ER homeostasis and the UPR to enhance treatment efficacy of acute myeloid leukemia

M Śniegocka, F Liccardo, F Fazi, S Masciarelli - Drug Resistance Updates, 2022 - Elsevier
Protein biogenesis, maturation and degradation are tightly regulated processes that are
governed by a complex network of signaling pathways. The endoplasmic reticulum (ER) is …

Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions

S Valdebenito, S Malik, R Luu, O Loudig, M Mitchell… - Scientific reports, 2021 - nature.com
Cell-to-cell communication is essential for the development and proper function of
multicellular systems. We and others demonstrated that tunneling nanotubes (TNT) …

Tunneling nanotube-mediated intercellular vesicle and protein transfer in the stroma-provided imatinib resistance in chronic myeloid leukemia cells

MD Kolba, W Dudka, M Zaręba-Kozioł, A Kominek… - Cell death & …, 2019 - nature.com
Intercellular communication within the bone marrow niche significantly promotes
leukemogenesis and provides protection of leukemic cells from therapy. Secreted factors …

NF-κB: a druggable target in acute myeloid leukemia

B Di Francesco, D Verzella, D Capece, D Vecchiotti… - Cancers, 2022 - mdpi.com
Simple Summary AML is a highly heterogeneous hematological disease and is the second
most common form of leukemia. Around 40% of AML patients display elevated nuclear NF …

The role of metabolism and tunneling nanotube-mediated intercellular mitochondria exchange in cancer drug resistance

Y Hekmatshoar, J Nakhle, M Galloni… - Biochemical …, 2018 - portlandpress.com
Intercellular communications play a major role in tissue homeostasis. In pathologies such as
cancer, cellular interactions within the tumor microenvironment (TME) contribute to tumor …

Cell communication by tunneling nanotubes: Implications in disease and therapeutic applications

R Mittal, E Karhu, JS Wang, S Delgado… - Journal of cellular …, 2019 - Wiley Online Library
Intercellular communication is essential for the development and maintenance of
multicellular organisms. Tunneling nanotubes (TNTs) are a recently recognized means of …

Chemotherapy-induced tunneling nanotubes mediate intercellular drug efflux in pancreatic cancer

S Desir, P O'Hare, RI Vogel, W Sperduto, A Sarkari… - Scientific reports, 2018 - nature.com
Intercellular communication plays a critical role in the ever-evolving landscape of invasive
cancers. Recent studies have elucidated the potential role of tunneling nanotubes (TNTs) in …

Mitochondrial transfer in the leukemia microenvironment

E Griessinger, R Moschoi, G Biondani, JF Peyron - Trends in cancer, 2017 - cell.com
The bone marrow microenvironment (BMME) is a complex ecosystem that instructs and
protects hematopoietic stem cells (HSCs) and their malignant counterparts, the leukemia …

Tunneling nanotubes: The intercellular conduits contributing to cancer pathogenesis and its therapy

PK Melwani, BN Pandey - Biochimica et Biophysica Acta (BBA)-Reviews …, 2023 - Elsevier
Tunneling nanotubes (TNTs) are intercellular conduits, which meet the communication
needs of non-adjacent cells situated in the same tissue but at distances up to a few hundred …