Anatomy, Function, and Dysfunction of the Right Ventricle: JACC State-of-the-Art Review

J Sanz, D Sánchez-Quintana, E Bossone… - Journal of the American …, 2019 - jacc.org
There is increasing recognition of the crucial role of the right ventricle (RV) in determining
functional status and prognosis in multiple conditions. The normal RV is anatomically and …

The physiological basis of pulmonary arterial hypertension

R Naeije, MJ Richter, LJ Rubin - European Respiratory Journal, 2022 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a rare dyspnoea-fatigue syndrome caused by a
progressive increase in pulmonary vascular resistance and eventual right ventricular (RV) …

Validation of the tricuspid annular plane systolic excursion/systolic pulmonary artery pressure ratio for the assessment of right ventricular-arterial coupling in severe …

K Tello, J Wan, A Dalmer, R Vanderpool… - Circulation …, 2019 - Am Heart Assoc
Background: The ratios of tricuspid annular plane systolic excursion (TAPSE)/
echocardiographically measured systolic pulmonary artery pressure (PASP), fractional area …

Reserve of right ventricular-arterial coupling in the setting of chronic overload

K Tello, A Dalmer, J Axmann, R Vanderpool… - Circulation: Heart …, 2019 - Am Heart Assoc
Background: Right ventricular (RV) maladaptation and failure determine outcome in
pulmonary hypertension. The adaptation of RV function to loading (RV-pulmonary arterial …

Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca2+ signaling

A Balistrieri, A Makino, JXJ Yuan - Physiological reviews, 2023 - journals.physiology.org
The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …

Pathophysiology of the right ventricle in health and disease: an update

K Tello, R Naeije, F de Man… - Cardiovascular research, 2023 - academic.oup.com
The contribution of the right ventricle (RV) to cardiac output is negligible in normal resting
conditions when pressures in the pulmonary circulation are low. However, the RV becomes …

Mechanisms and treatment of pulmonary arterial hypertension

HA Ghofrani, M Gomberg-Maitland, L Zhao… - Nature Reviews …, 2024 - nature.com
Substantial progress has been made in the management of pulmonary arterial hypertension
(PAH) in the past 25 years, but the disease remains life-limiting. Established therapies for …

Cardiac magnetic resonance imaging-based right ventricular strain analysis for assessment of coupling and diastolic function in pulmonary hypertension

K Tello, A Dalmer, R Vanderpool, HA Ghofrani… - JACC: Cardiovascular …, 2019 - jacc.org
Objectives: This study sought to compare cardiac magnetic resonance (CMR) imaging-
derived right ventricular (RV) strain and invasively measured pressure-volume loop-derived …

Right heart failure in pulmonary hypertension: diagnosis and new perspectives on vascular and direct right ventricular treatment

K Tello, W Seeger, R Naeije… - British journal of …, 2021 - Wiley Online Library
Adaptation of right ventricular (RV) function to increased afterload—known as RV–arterial
coupling—is a key determinant of prognosis in pulmonary hypertension. However …

[HTML][HTML] Mechanics of right ventricular dysfunction in pulmonary arterial hypertension and heart failure with preserved ejection fraction

RJ Bernardo, F Haddad, EJ Couture… - Cardiovascular …, 2020 - ncbi.nlm.nih.gov
Right ventricular (RV) dysfunction is the most important determinant of survival in patients
with pulmonary hypertension (PH). The manifestations of RV dysfunction not only include …