Optical imaging represents one of the most essential tools in biological studies. Although
with great advances, bio-optical imaging still suffers from problems such as resolution …

The long-dreamed-of capability of monitoring the molecular machinery in living systems has
not been realized yet, mainly due to the technical limitations of current sensing technologies …

Gold nanoparticles have been used in biomedical applications since their first colloidal
syntheses more than three centuries ago. However, over the past two decades, their …

In the past decade, mammalian cells have increasingly encountered gold nanoparticles
(GNPs), owing to the active development of nanomedicine. 1− 3 GNPs have been more and …

In his 1665 treatise, Micrographia, Robert Hooke described the many observations he had
made using a microscope, including compartment-like structures in cork samples that he …

Nanoparticle uptake by cells has been studied for applications both in nanomedicine and in
nanosafety. While the majority of studies have focused on the biological mechanisms …

A strong intrinsic signal is advantageous over labeling for optical detection of nanoparticles.
Intense scattering and absorption by the surface plasmon resonance, which exceeds …

Dynamin has an important role in clathrin-mediated endocytosis by cutting the neck of
nascent vesicles from the cell membrane. Here, using gold nanorods as cargos to image …

The cellular uptake of nanoparticles (NPs) has drawn significant attention due to their great
importance and potential in drug delivery, bioimaging, and specific targeting. Here, we …

The cell uptake rate of nanoparticles (NPs) coated with mixed hydrophilic/hydrophobic
ligands is known to be strongly influenced by the ligand pattern on the nanoparticle surface …