Advances in the colon-targeted chitosan based multiunit drug delivery systems for the treatment of inflammatory bowel disease

N Kulkarni, P Jain, A Shindikar, P Suryawanshi… - Carbohydrate …, 2022 - Elsevier
Chitosan is the polymer of choice for delivery of the active moieties to the colon due to its
cationic nature that enables strong mucosal attachment. Chitosan is explored for …

The future of biosimilars: maximizing benefits across immune-mediated inflammatory diseases

HU Kim, R Alten, L Avedano, A Dignass, F Gomollón… - Drugs, 2020 - Springer
Biologics have transformed the treatment of immune-mediated inflammatory diseases such
as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). Biosimilars—biologic …

Engineered microbial systems for advanced drug delivery

H Shen, N Aggarwal, KS Wun, YS Lee… - Advanced Drug Delivery …, 2022 - Elsevier
The human body is a natural habitat for a multitude of microorganisms, with bacteria being
the major constituent of the microbiota. These bacteria colonize discrete anatomical …

[HTML][HTML] Site-specific targeted drug delivery systems for the treatment of inflammatory bowel disease

X Li, C Lu, Y Yang, C Yu, Y Rao - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative colitis and
manifests as a complex and dysregulated immune response. To date, there is no cure for …

Fecal microbiota transplant–a new frontier in inflammatory bowel disease

T Sunkara, P Rawla, A Ofosu… - Journal of inflammation …, 2018 - Taylor & Francis
Inflammatory bowel disease (IBD) is a chronic multifactorial disease that affects the
gastrointestinal tract and results from an aberrant immune response toward luminal antigens …

Real‐world evidence on adherence, persistence, switching and dose escalation with biologics in adult inflammatory bowel disease in the United States: a systematic …

S Khan, E Rupniewska, M Neighbors… - Journal of clinical …, 2019 - Wiley Online Library
What is known and objective The application of biologics to treat inflammatory bowel
disease (IBD), including Crohn's disease and ulcerative colitis, is well established. Our aim …

Dietary strategies for maintenance of clinical remission in inflammatory bowel diseases: are we there yet?

K Gkikas, K Gerasimidis, S Milling, UZ Ijaz, R Hansen… - Nutrients, 2020 - mdpi.com
The etiopathogenesis of Inflammatory bowel disease (IBD) is a result of a complex
interaction between host immune response, the gut microbiome and environmental factors …

Neuro-immune circuits regulate immune responses in tissues and organ homeostasis

MO Jakob, S Murugan, CSN Klose - Frontiers in immunology, 2020 - frontiersin.org
The dense innervation of the gastro-intestinal tract with neuronal networks, which are in
close proximity to immune cells, implies a pivotal role of neurons in modulating immune …

Innovations in oral therapies for inflammatory bowel disease

C Ma, R Battat, PS Dulai, CE Parker, WJ Sandborn… - Drugs, 2019 - Springer
Prior to the biologic era, the medical management of patients with inflammatory bowel
disease (IBD) was dominated by the use of aminosalicylates, corticosteroids, and …

Application of chitosan as nano carrier in the treatment of inflammatory bowel disease

X Liu, Y Dong, C Wang, Z Guo - International Journal of Biological …, 2024 - Elsevier
Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's
disease (CD), is characterized by persistent and recurrent gastrointestinal inflammation …