On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?

E Roohi, N Jaafari, F Hashemian - Journal of neuroinflammation, 2021 - Springer
Many patients with major depressive disorder (MDD) are reported to have higher levels of
multiple inflammatory cytokines including interleukin 6 (IL-6). Recent studies both pre …

[HTML][HTML] Cytokine research in depression: principles, challenges, and open questions

H Himmerich, O Patsalos, N Lichtblau… - Frontiers in …, 2019 - frontiersin.org
Cytokines have been implicated in the pathology of depression. Currently, the evidence is
based on cross-sectional studies and meta-analytic research comparing blood …

Food insecurity as a driver of obesity in humans: The insurance hypothesis

D Nettle, C Andrews, M Bateson - Behavioral and Brain Sciences, 2017 - cambridge.org
Integrative explanations of why obesity is more prevalent in some sectors of the human
population than others are lacking. Here, we outline and evaluate one candidate …

Immune system to brain signaling: neuropsychopharmacological implications

L Capuron, AH Miller - Pharmacology & therapeutics, 2011 - Elsevier
There has been an explosion in our knowledge of the pathways and mechanisms by which
the immune system can influence the brain and behavior. In the context of inflammation, pro …

A review of the association between obesity and cognitive function across the lifespan: implications for novel approaches to prevention and treatment

E Smith, P Hay, L Campbell, JN Trollor - Obesity reviews, 2011 - Wiley Online Library
Recent research suggests that increased adiposity is associated with poor cognitive
performance, independently of associated medical conditions. The evidence regarding this …

Examining the relationship between obesity and cognitive function: a systematic literature review

C Prickett, L Brennan, R Stolwyk - Obesity research & clinical practice, 2015 - Elsevier
The increasing prevalence of both obesity and dementia is a significant public health
concern, especially as recent research demonstrates a significant relationship between …

Disinhibited eating in obese adolescents is associated with orbitofrontal volume reductions and executive dysfunction

L Maayan, C Hoogendoorn, V Sweat, A Convit - Obesity, 2011 - Wiley Online Library
In adults, obesity has been associated with disinhibited eating, decreased cortical gray
matter (GM) volume, and lower performance on cognitive assessments. Much less is known …

Gut to brain dysbiosis: mechanisms linking western diet consumption, the microbiome, and cognitive impairment

EE Noble, TM Hsu, SE Kanoski - Frontiers in behavioral neuroscience, 2017 - frontiersin.org
Consumption of a Western Diet (WD) that is high in saturated fat and added sugars
negatively impacts cognitive function, particularly mnemonic processes that rely on the …

Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: focus on brain indoleamine 2, 3 …

C Andre, AL Dinel, G Ferreira, S Laye… - Brain, behavior, and …, 2014 - Elsevier
Obesity is associated with a high prevalence of mood symptoms and cognitive dysfunctions
that emerges as significant risk factors for important health complications such as …

Structural brain differences and cognitive functioning related to body mass index in older females

K Walther, AC Birdsill, EL Glisky… - Human brain …, 2010 - Wiley Online Library
Little is known about the effect of obesity on brain structures and cognition in healthy older
adults. This study examined the association between body mass index (BMI), regional …