Abstract Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …

The liver plays critical roles in both homeostasis and pathology. It is the major site of drug
metabolism in the body and, as such, a common target for drug-induced toxicity and is …

This paper describes the development and characterization of a microphysiology platform
for drug safety and efficacy in liver models of disease that includes a human, 3D …

Microphysiology systems (MPS), also called organs-on-chips and tissue chips, are
miniaturized functional units of organs constructed with multiple cell types under a variety of …

The high rate of failure during drug development is well-known, however recent advances in
tissue engineering and microfabrication have contributed to the development of …

The vLAMPS is a human, biomimetic liver MPS, in which the ECM and cell seeding of the
intermediate layer prior to assembly, simplifies construction of the model and makes the …

This article describes our next generation human Liver Acinus MicroPhysiology System
(LAMPS). The key demonstration of this study was that Zone 1 and Zone 3 …

High-content screening (HCS) technology combining automated microscopy and
quantitative image analysis can address biological questions in academia and the …

Microphysiological systems (MPSs), also known as organ-on-a-chip models, aim to
recapitulate the functional components of human tissues or organs in vitro. Over the last …

The liver is a highly metastasis-permissive organ, tumor seeding of which usually portends
mortality. Its unique and diverse architectural and cellular composition enable the liver to …