Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides
regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the …

Tissue development and homeostasis are controlled by mechanical cues. Perturbation of
the mechanical equilibrium triggers restoration of mechanostasis through changes in cell …

The intermediate filament (IF) cytoskeleton has been proposed to regulate morphogenic
processes by integrating the cell fate signaling machinery with mechanical cues. Signaling …

The mechanical regulation of Notch signaling is an emerging area of interest in cell biology.
Notch is essential in many physiological processes in which mechanical stress plays an …

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors to control
cell fate in many developmental and adult tissue contexts. Notch signalling continues to be …

Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the
main embryonic arteries. The onset of circulation triggers several processes that provide …

Favouring or thwarting the development of a vascular network is essential in fields as
diverse as oncology, cardiovascular disease or tissue engineering. As a result …

BACKGROUND: Computational modeling indicated that pathological high shear stress
(HSS; 100 dyn/cm2) is generated in pulmonary arteries (PAs; 100–500 µm) in congenital …

The Notch signaling pathway uses families of ligands and receptors to transmit signals to
nearby cells. These components are expressed in diverse combinations in different cell …

Aims During embryonic development, arteriovenous (AV) differentiation ensures proper
blood vessel formation and maturation. Defects in arterial or venous identity cause …