Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging

G David, S Mohammadi, AR Martin… - Nature Reviews …, 2019 - nature.com
Pathophysiological changes in the spinal cord white and grey matter resulting from injury
can be observed with MRI techniques. These techniques provide sensitive markers of …

MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers

P Freund, M Seif, N Weiskopf, K Friston… - The Lancet …, 2019 - thelancet.com
Traumatic spinal cord injury occurs when an external physical impact damages the spinal
cord and leads to permanent neurological dysfunction and disability, and it is associated …

Guidelines for the conduct of clinical trials in spinal cord injury: Neuroimaging biomarkers

M Seif, CAM Gandini Wheeler-Kingshott… - Spinal Cord, 2019 - nature.com
Traumatic spinal cord injury (SCI) leads to immediate neuronal and axonal damage at the
focal injury site and triggers secondary pathologic series of events resulting in sensorimotor …

Tracking white and gray matter degeneration along the spinal cord axis in degenerative cervical myelopathy

K Vallotton, G David, M Hupp, N Pfender… - Journal of …, 2021 - liebertpub.com
This study aims to determine tissue-specific neurodegeneration across the spinal cord in
patients with mild-moderate degenerative cervical myelopathy (DCM). Twenty-four mild …

Extent of cord pathology in the lumbosacral enlargement in non-traumatic versus traumatic spinal cord injury

G David, K Vallotton, M Hupp, A Curt… - Journal of …, 2022 - liebertpub.com
This study compares remote neurodegenerative changes caudal to a cervical injury in
degenerative cervical myelopathy (DCM; ie, non-traumatic) and incomplete traumatic spinal …

Lower motoneuron dysfunction impacts spontaneous motor recovery in acute cervical spinal cord injury

S Franz, U Eck, C Schuld, L Heutehaus… - Journal of …, 2023 - liebertpub.com
Paresis after spinal cord injury (SCI) is caused by damage to upper and lower motoneurons
(LMNs) and may differentially impact neurological recovery. This prospective monocentric …

Longitudinal changes of spinal cord grey and white matter following spinal cord injury

G David, D Pfyffer, K Vallotton, N Pfender… - Journal of Neurology …, 2021 - jnnp.bmj.com
Objectives Traumatic and non-traumatic spinal cord injury produce neurodegeneration
across the entire neuraxis. However, the spatiotemporal dynamics of spinal cord grey and …

Spinal cord atrophy after spinal cord injury–A systematic review and meta-analysis

C Trolle, E Goldberg, C Linnman - NeuroImage: Clinical, 2023 - Elsevier
Cervical spinal cord atrophy occurs after spinal cord injury. The atrophy and how level of
injury affects atrophy differs between studies. A systematic review and metaanalysis were …

Improving diagnostic workup following traumatic spinal cord injury: advances in biomarkers

S Schading, TM Emmenegger, P Freund - Current neurology and …, 2021 - Springer
Abstract Purpose of Review Traumatic spinal cord injury (SCI) is a life-changing event with
drastic implications for patients due to sensorimotor impairment and autonomous …

Phrenic motor neuron survival below cervical spinal cord hemisection

LL Allen, NL Nichols, ZA Asa, AT Emery… - Experimental …, 2021 - Elsevier
Cervical spinal cord injury (cSCI) severs bulbospinal projections to respiratory motor
neurons, paralyzing respiratory muscles below the injury. C2 spinal hemisection (C2Hx) is a …