The prevailing notion that reduced cofactors NADH and FADH 2 transfer electrons from the
tricarboxylic acid cycle to the mitochondrial electron transfer system creates ambiguities …

Hearing loss is a prevalent condition affecting millions of people worldwide. Hearing loss
has been linked to oxidative stress as a major factor in its onset and progression. The goal of …

Friedreich's ataxia (FRDA) is a rare childhood neurologic disorder, affecting 1 in 50,000
Caucasians. The disease is caused by the abnormal expansion of the GAA repeat sequence …

Let us first start where we all agree: KATP channels are the main conductance of the resting
pancreatic b-cell, and their closure by changes in the ATP/ADP ratio is the triggering …

Sarcopenia is a progressive muscle wasting disorder that severely impacts the quality of life
of elderly individuals. Although the natural aging process primarily causes sarcopenia, it can …

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as
nonalcoholic fatty liver disease (NAFLD), encompasses a range of liver conditions from …

The life shortening nature of Friedreich Ataxia (FRDA) demands the search for therapies that
can delay, stop or reverse its relentless trajectory. This review provides a contemporary …

Peripheral mononuclear cells (PBMCs) exhibit robust changes in mitochondrial respiratory
capacity in response to health and disease. While these changes do not always reflect what …

Peripheral mononuclear cells (PBMCs) exhibit robust changes in mitochondrial respiratory
capacity in response to health and disease. While these changes do not always reflect what …

Aging-related decreases in cardiac and skeletal muscle function are strongly associated
with various comorbidities. Elamipretide (ELAM), a novel mitochondrial-targeted peptide …