Advances in immunosuppressive agents based on signal pathway

Z Xu, M Chu - Frontiers in Pharmacology, 2022 - frontiersin.org
Immune abnormality involves in various diseases, such as infection, allergic diseases,
autoimmune diseases, as well as transplantation. Several signal pathways have been …

Relevance of the Platelet-activating factor system in chemical warfare agents-induced effects

A Thyagarajan, JB Travers, RP Sahu - Free Radical Biology and Medicine, 2024 - Elsevier
The threats to chemical warfare-associated agents (CWA), including nitrogen mustard, are
increasing, and no direct antidote is currently available to mitigate the deleterious cutaneous …

[HTML][HTML] NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns

R Surolia, FJ Li, Z Wang, M Kashyap, RK Srivastava… - JCI insight, 2021 - ncbi.nlm.nih.gov
Despite the high morbidity and mortality among patients with extensive cutaneous burns in
the intensive care unit due to the development of acute respiratory distress syndrome …

[HTML][HTML] Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability

AS Hari, R Banerji, LP Liang, RE Fulton, CQ Huynh… - Redox Biology, 2023 - Elsevier
Glutathione (GSH) depletion, and impaired redox homeostasis have been observed in
experimental animal models and patients with epilepsy. Pleiotropic strategies that elevate …

Enhanced transdermal delivery of N-acetylcysteine and 4-phenylbutyric acid for potential use as antidotes to lewisite

AA Dandekar, D Vora, JS Yeh, RK Srivastava… - AAPS …, 2023 - Springer
Lewisite is a highly toxic chemical warfare agent that leads to cutaneous and systemic
damage. N-acetylcysteine (NAC) and 4-phenylbutryic acid (4-PBA) are two novel antidotes …

Painless photodynamic therapy triggers innate and adaptive immune responses in a murine model of UV‐induced squamous skin pre‐cancer

S Anand, M Govande, A Yasinchak… - Photochemistry and …, 2021 - Wiley Online Library
Painless photodynamic therapy (p‐PDT), which involves application of photosensitizer and
immediate exposure to light to treat actinic keratosis (AK) in patients, causes negligible pain …

Retinal injury mouse model and pathophysiological assessment of the effect of arsenical vesicants

A Zhylkibayev, R Srivastava, P Anantharam… - Experimental eye …, 2023 - Elsevier
The eye is ten times more vulnerable to chemical warfare agents than other organs.
Consistently, exposure to vesicant arsenical lewisite (LEW) manifests significant corneal …

Arsenic and heavy metals at Japanese abandoned chemical weapons site in China: distribution characterization, source identification and contamination risk …

C Ji, Y Zhu, S Zhao, H Zhang, S Wang, J Zhou… - Environmental …, 2023 - Springer
As-containing chemical weapons (CWs) and their degraded products pose a great threat to
the environment and to human health. In this study, concentration and distribution …

Cutaneous exposure to lewisite causes acute kidney injury by invoking DNA damage and autophagic response

RK Srivastava, AM Traylor, C Li… - American Journal …, 2018 - journals.physiology.org
Lewisite (2-chlorovinyldichloroarsine) is an organic arsenical chemical warfare agent that
was developed and weaponized during World Wars I/II. Stockpiles of lewisite still exist in …

Phenylarsine oxide induced corneal injury involves oxidative stress mediated unfolded protein response and ferroptotic cell death: Amelioration by NAC

K Kandhari, R Kant, N Mishra, C Agarwal… - Free Radical Biology and …, 2023 - Elsevier
Phenylarsine oxide (PAO), an analog of lewisite, is a highly toxic trivalent arsenical and a
potential chemical warfare agent. PAO-induced toxicity has been studied in lung, liver, and …