Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell
lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and …

Atopic dermatitis is a chronic, non-infectious inflammatory dermatosis. Acharacteristic
feature is persistent itching of the skin. The chronic, relapsing course of the disease …

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Genetic
predisposition, epidermal barrier disruption, and dysregulation of the immune system are …

The airway epithelium protects us from environmental insults, which we encounter with
every breath. Not only does it passively filter large particles, it also senses potential danger …

Background In some patients with moderate-to-severe asthma, particularly those with
noneosinophilic inflammation, the disease remains uncontrolled. This trial evaluated the …

The epithelial cell–derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25
are central regulators of type 2 immunity, which drives a broad array of allergic responses …

Mammals have evolved neurophysiologic reflexes, such as coughing and scratching, to
expel invading pathogens and noxious environmental stimuli. It is well established that …

More than a decade ago, type 2 innate lymphoid cells (ILC2s) were discovered to be
members of a family of innate immune cells consisting of five subsets that form a first line of …

Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2
cytokines in response to a variety of stimuli, including the epithelial cytokines interleukin (IL) …

Research over the last 7 years has led to the formal identification of innate lymphoid cells
(ILCs), increased the understanding of their tissue distribution and has established essential …