Modifications in an emergency: the role of N1-methylpseudouridine in COVID-19 vaccines
The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired
one of the most efficient vaccine development campaigns in human history. A key aspect of …
one of the most efficient vaccine development campaigns in human history. A key aspect of …
The challenge and prospect of mRNA therapeutics landscape
Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …
in the pharmaceutical industry because they can be used for precise and individualized …
[HTML][HTML] The critical contribution of pseudouridine to mRNA COVID-19 vaccines
P Morais, H Adachi, YT Yu - Frontiers in cell and developmental …, 2021 - frontiersin.org
The current COVID-19 pandemic is a massive source of global disruption, having led so far
to two hundred million COVID-19 cases and more than four million deaths worldwide. It was …
to two hundred million COVID-19 cases and more than four million deaths worldwide. It was …
Three decades of messenger RNA vaccine development
R Verbeke, I Lentacker, SC De Smedt, H Dewitte - Nano Today, 2019 - Elsevier
In the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool
for vaccination. In the following decades, an improved understanding of the mRNA …
for vaccination. In the following decades, an improved understanding of the mRNA …
[HTML][HTML] mRNA-based therapeutics—developing a new class of drugs
In vitro transcribed (IVT) mRNA has recently come into focus as a potential new drug class to
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …
[HTML][HTML] SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/8
V Salvi, HO Nguyen, F Sozio, T Schioppa, C Gaudenzi… - JCI insight, 2021 - ncbi.nlm.nih.gov
The inflammatory and IFN pathways of innate immunity play a key role in the resistance and
pathogenesis of coronavirus disease 2019 (COVID-19). Innate sensors and SARS-CoV-2 …
pathogenesis of coronavirus disease 2019 (COVID-19). Innate sensors and SARS-CoV-2 …
Therapeutic oligonucleotides: state of the art
CIE Smith, R Zain - Annual review of pharmacology and …, 2019 - annualreviews.org
Oligonucleotides (ONs) can interfere with biomolecules representing the entire extended
central dogma. Antisense gapmer, steric block, splice-switching ONs, and short interfering …
central dogma. Antisense gapmer, steric block, splice-switching ONs, and short interfering …
Nanomedicines to deliver mRNA: state of the art and future perspectives
I Gómez-Aguado, J Rodríguez-Castejón… - Nanomaterials, 2020 - mdpi.com
The use of messenger RNA (mRNA) in gene therapy is increasing in recent years, due to its
unique features compared to plasmid DNA: Transient expression, no need to enter into the …
unique features compared to plasmid DNA: Transient expression, no need to enter into the …
mRNA vaccines: The future of prevention of viral infections?
P Rzymski, A Szuster‐Ciesielska… - Journal of medical …, 2023 - Wiley Online Library
Messenger RNA (mRNA) vaccines against COVID‐19 are the first authorized biological
preparations developed using this platform. During the pandemic, their administration has …
preparations developed using this platform. During the pandemic, their administration has …
Uridine depletion and chemical modification increase Cas9 mRNA activity and reduce immunogenicity without HPLC purification
S Vaidyanathan, KT Azizian, AKMA Haque… - … Therapy-Nucleic Acids, 2018 - cell.com
The Cas9/guide RNA (Cas9/gRNA) system is commonly used for genome editing. mRNA
expressing Cas9 can induce innate immune responses, reducing Cas9 expression. First …
expressing Cas9 can induce innate immune responses, reducing Cas9 expression. First …