Oligodendrocyte (OL) myelination is a critical process for the neuronal axon function in the
central nervous system. After demyelination occurs because of pathophysiology …

Hypoplastic left heart syndrome (HLHS) is a lethal congenital heart disease (CHD) affecting
8–25 per 100,000 neonates globally. Clinical interventions, primarily surgical, have …

Oligodendrocytes (OLs) produce myelin in the central nervous system (CNS), which
accelerates the propagation of action potentials and supports axonal integrity. As a major …

Oligodendrocytes (OLs) produce myelin sheaths around axons in the central nervous
system (CNS). Myelin accelerates the propagation of action potentials along axons and …

High-throughput DNA sequencing studies increasingly associate DNA variants with
congenital heart disease (CHD). However, functional modeling is a crucial prerequisite for …

Background Cardiac‐urogenital syndrome [MIM# 618280] is a newly described very rare
syndrome associated with pathogenic variants in the myelin regulatory factor (MYRF) gene …

Abstract The Myelin Regulator Factor (MYRF) is a master regulator governing myelin
formation and maintenance in the central nervous system. The conservation of MYRF across …

Background: MYRF-related mild encephalopathy with reversible myelin vacuolization
(MMERV) is an inherited neurological disorder characterized by dysfunction in the central …

Abstract Cardiac-Urogenital Syndrome (CUGS) is a recently identified genetic disease
characterized by urogenital, diaphragmatic, ophthalmic, and cardiac abnormalities caused …

An emerging feature of demyelinating disorders or events following peripheral nerve injury
is the accumulation of misfolded proteins in myelinating glia leading to activation of the …