The nasal route has been used for many years for the local treatment of nasal diseases.
More recently, this route has been gaining momentum, due to the possibility of targeting the …

Objective To review the airway microbiome in chronic obstructive pulmonary disease
(COPD), bronchiectasis and bronchiectasis‐COPD overlap (BCO). Data source and study …

There is an unmet need for preclinical models to understand the pathogenesis of human
respiratory viruses and predict responsiveness to immunotherapies. Airway organoids can …

Chronic rhinosinusitis (CRS) is a debilitating condition characterized by long-lasting
inflammation of the paranasal sinuses. It affects a significant portion of the population …

In recent years, there has been a significant increase in the registration of drugs for nasal
application with systemic effects. Previous preclinical in vitro test systems for transmucosal …

Live biotherapeutic products (LBP) are emerging as alternative treatment strategies for
chronic rhinosinusitis. The selection of interesting candidate LBPs often involves model …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) environmental
contamination occurs through droplets and biological fluids released in the surroundings …

The epithelium of the human sinonasal cavities is colonized by a diverse microbial
community, modulating epithelial development and immune priming and playing a role in …

Abstract Live Attenuated Influenza Virus (LAIV) is administered to and replicates in the
sinonasal epithelium. Candidate LAIV vaccine strains are selected based on their ability to …

nasal passages, from the nostrils to the upper part of the throat, are home to a distinct
community of bacterial species, the nasal microbiota. Most likely, you rarely think about your …