The rise of antibiotic resistance and the reduced amount of novel antibiotics support the
need of developing novel strategies to fight infections, based on improving the use of the …

Genetic networks are surprisingly robust to perturbations caused by new mutations. This
robustness is conferred in part by compensation for loss of a gene's activity by genes with …

Background Cells and tissues have a remarkable ability to adapt to genetic perturbations via
a variety of molecular mechanisms. Nonsense-induced transcriptional compensation, a form …

Gene knockout disrupts cellular homeostasis, altering gene expression, and phenotypes.
We investigated whether cells return to their pre-knockout transcriptomic state through …

Complexity in biology is often described using a multi-map hierarchical architecture, where
the genotype, representing the encoded information, is mapped to the functional level …

The mammalian HMGB1 is a high-mobility-group B protein, which is both an architectural
and functional element of chromatin. Nhp6p, the extensively studied fungal homologue of …

The fitness cost of complex pleiotropic mutations is generally difficult to assess. On the one
hand, it is necessary to identify which molecular properties are directly altered by the …

In Saccharomyces cerevisiae, the transcription factor GCR1 plays a vital role in
carbohydrate metabolism and in the current study we tried to elucidate its role in lipid …

The mammalian HMGB1 protein belongs to the high-mobility-group B (HMG-B) family, which
is not only architectural but also functional element of the chromatin. The fungal counterpart …

The fitness cost of complex pleiotropic mutations is generally difficult to assess. On the one
hand, it is necessary to identify which molecular properties are directly altered by the …