Epidemiology and treatment of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa infections

JP Horcajada, M Montero, A Oliver, L Sorlí… - Clinical microbiology …, 2019 - Am Soc Microbiol
In recent years, the worldwide spread of the so-called high-risk clones of multidrug-resistant
or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa has become a public …

The increasing threat of Pseudomonas aeruginosa high-risk clones

A Oliver, X Mulet, C López-Causapé, C Juan - Drug Resistance Updates, 2015 - Elsevier
The increasing prevalence of chronic and hospital-acquired infections produced by
multidrug-resistant (MDR) or extensively drug-resistant (XDR) Pseudomonas aeruginosa …

[HTML][HTML] High rate of colistin resistance among patients with carbapenem-resistant Klebsiella pneumoniae infection accounts for an excess of mortality

A Capone, M Giannella, D Fortini, A Giordano… - Clinical Microbiology …, 2013 - Elsevier
Carbapenem-resistant Klebsiella pneumoniae (CR-KP) is becoming a common cause of
healthcare-associated infection in Italy, with high morbidity and mortality. Prevalent CR-KP …

Mechanisms leading to in vivo ceftolozane/tazobactam resistance development during the treatment of infections caused by MDR Pseudomonas aeruginosa

PA Fraile-Ribot, G Cabot, X Mulet… - Journal of …, 2018 - academic.oup.com
Objectives Characterization of the mechanisms driving ceftolozane/tazobactam resistance
development in 5 of 47 (10.6%) patients treated for MDR Pseudomonas aeruginosa …

Ceftolozane/tazobactam for the treatment of serious Pseudomonas aeruginosa infections: a multicentre nationwide clinical experience

M Bassetti, N Castaldo, A Cattelan, C Mussini… - International journal of …, 2019 - Elsevier
This study describes the largest clinical experience using ceftolozane/tazobactam (C/T) for
different Pseudomonas aeruginosa infections. A retrospective study was performed at 22 …

Influence of Virulence Genotype and Resistance Profile in the Mortality of Pseudomonas aeruginosa Bloodstream Infections

C Peña, G Cabot, S Gómez-Zorrilla… - Clinical Infectious …, 2015 - academic.oup.com
Using a large multicenter prospective cohort of Pseudomonas aeruginosa bacteremia, we
demonstrate that the exoU type III secretion system genotype is independently associated …

Interplay between antibiotic resistance and virulence during disease promoted by multidrug-resistant bacteria

E Geisinger, RR Isberg - The Journal of infectious diseases, 2017 - academic.oup.com
Diseases caused by antibiotic-resistant bacteria in hospitals are the outcome of complex
relationships between several dynamic factors, including bacterial pathogenicity, the fitness …

Genomics and susceptibility profiles of extensively drug-resistant Pseudomonas aeruginosa isolates from Spain

E del Barrio-Tofiño, C López-Causapé… - Antimicrobial agents …, 2017 - Am Soc Microbiol
This study assessed the molecular epidemiology, resistance mechanisms, and susceptibility
profiles of a collection of 150 extensively drug-resistant (XDR) Pseudomonas aeruginosa …

Host and Pathogen Biomarkers for Severe Pseudomonas aeruginosa Infections

C Juan, C Peña, A Oliver - The Journal of infectious diseases, 2017 - academic.oup.com
Pseudomonas aeruginosa is among the leading causes of severe nosocomial infections,
particularly affecting critically ill and immunocompromised patients. Here we review the …

Genetic markers of widespread extensively drug-resistant Pseudomonas aeruginosa high-risk clones

G Cabot, AA Ocampo-Sosa… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Recent reports have revealed the existence of widespread extensively drug-resistant (XDR)
P. aeruginosa high-risk clones in health care settings, but there is still scarce information on …