Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved cellular
process capable of degrading various biological molecules (eg, protein, glycogen, lipids …

Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize
cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors …

Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

The clearance of surplus, broken, or dangerous components is key for maintaining cellular
homeostasis. The failure to remove protein aggregates, damaged organelles, or intracellular …

Autophagosome formation and maturation involve the two ubiquitin-like systems: The ATG8
and ATG12 systems. ATG8 (LC3s and gamma-aminobutyric acid receptor–associated …

In selective autophagy, cytoplasmic components are selected and tagged before being
sequestered into an autophagosome by means of selective autophagy receptors such as …

Autophagy is a self-eating cellular catabolic pathway, through which long-lived proteins,
damaged organelles and misfolded proteins are degraded and recycled for the …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …

Autophagy, an evolutionarily conserved cellular degradation pathway of the lysosome, is
associated with many physiological and pathological processes. The hallmark of autophagy …

Autophagy is a highly conserved process and is essential for the maintenance of cellular
homeostasis. Autophagy occurs at a basal level in all cells, but it can be up-regulated during …