Approaches to study gap junctional coupling

J Stephan, S Eitelmann, M Zhou - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Astrocytes and oligodendrocytes are main players in the brain to ensure ion and
neurotransmitter homeostasis, metabolic supply, and fast action potential propagation in …

Gap junction-dependent and-independent functions of Connexin43 in biology

Y Zhu - Biology, 2022 - mdpi.com
Simple Summary Connexin43 is one of the 21 members of a large protein family that forms
intercellular gap junction complexes. It plays a critical role in development by allowing two …

Cx43 carboxyl terminal domain determines AQP4 and Cx30 endfoot organization and blood brain barrier permeability

A Cibelli, R Stout, A Timmermann, L de Menezes… - Scientific reports, 2021 - nature.com
The neurovascular unit (NVU) consists of cells intrinsic to the vessel wall, the endothelial
cells and pericytes, and astrocyte endfeet that surround the vessel but are separated from it …

Glioblastoma–Astrocyte Connexin 43 Gap Junctions Promote Tumor Invasion

S McCutcheon, DC Spray - Molecular Cancer Research, 2022 - AACR
Glioblastoma multiforme (GBM), classified as World Health Organization grade IV
astrocytoma, is the deadliest adult cancer of the central nervous system. An important …

Activity and stability of Panx1 channels in astrocytes and neuroblastoma cells are enhanced by cholesterol depletion

A Cibelli, E Scemes, DC Spray - Cells, 2022 - mdpi.com
Pannexin1 (Panx1) is expressed in both neurons and glia where it forms ATP-permeable
channels that are activated under pathological conditions such as epilepsy, migraine …

Targeting Rho kinase to restore endothelial barrier function following vascular scaffold implantation

B Tesfamariam - Drug Discovery Today, 2023 - Elsevier
Vascular scaffold implantation induces injury to the intimal layer and causes discontinuity of
the regenerated endothelial monolayer, compromising barrier integrity, increasing …

The Neural Stem Cell Properties of PKD2L1+ Cerebrospinal Fluid-Contacting Neurons in vitro

S Wang, Y He, H Zhang, L Chen, L Cao… - Frontiers in Cellular …, 2021 - frontiersin.org
Cerebrospinal fluid-touching neurons (CSF-cNs) exist in the region surrounding the central
canal of the spinal cord, which locate in the adult neurogenic niche. Previous research …

The nanoscopic organization of synapse structures: a common basis for cell communication

X Yang, W Annaert - Membranes, 2021 - mdpi.com
Synapse structures, including neuronal and immunological synapses, can be seen as the
plasma membrane contact sites between two individual cells where information is …

Role of Connexin 43 phosphorylation on Serine-368 by PKC in cardiac function and disease

R Pun, MH Kim, BJ North - Frontiers in cardiovascular medicine, 2023 - frontiersin.org
Intercellular communication mediated by gap junction channels and hemichannels
composed of Connexin 43 (Cx43) is vital for the propagation of electrical impulses through …

Understanding the Role of Connexins in Hepatocellular Carcinoma: Molecular and Prognostic Implications

SP Papadakos, E Chatzikalil, K Arvanitakis… - Cancers, 2024 - mdpi.com
Simple Summary Hepatocellular carcinoma represents the majority of all liver cancers and
the fourth cause of cancer-related deaths worldwide. Despite the progress in diagnostic and …