Although care of patients with heart failure (HF) has improved in the past decade, important
disparities in HF outcomes persist based on race/ethnicity. Age-adjusted HF-related …

Transthyretin cardiac amyloidosis (ATTR-CA) is increasingly diagnosed owing to the
emergence of noninvasive imaging and improved awareness. Clinical penetrance of …

The systemic amyloidoses are a broad spectrum of diseases that result from misfolding of
proteins that aggregate into b-sheet amyloid fibrils. Over 35 amyloidogenic precursor …

ACMG SF v3.1 list for reporting of secondary findings in clinical exome and genome
sequencing: A policy statement of the American College of Medical Genetics and Genomics …

Objectives Tafamidis is an effective treatment for transthyretin amyloid cardiomyopathy
(ATTR-CM), this study aimed to determine whether there is a differential effect between …

The Penn Medicine BioBank (PMBB) is an electronic health record (EHR)-linked biobank at
the University of Pennsylvania (Penn Medicine). A large variety of health-related information …

ATTR amyloidosis is caused by systemic deposition of transthyretin (TTR) and comprises
ATTRwt (wt for wild-type) amyloidosis, ATTRv (v for variant) amyloidosis, and acquired ATTR …

Aim Systematic evidence on the prevalence and clinical outcome of transthyretin
amyloidosis (ATTR) is missing. We explored:(i) the prevalence of cardiac amyloidosis in …

Aim Predicting progression in diabetic kidney disease (DKD) is critical to improving
outcomes. We sought to develop/validate a machine-learned, prognostic risk score …

Importance Systemic amyloidosis from transthyretin (ATTR) protein is the most common type
of amyloidosis that causes cardiomyopathy. Observations Transthyretin (TTR) protein …