Carbon dots (CDs) are an emerging class of nanomaterials with attractive optical properties,
which promise to enable a variety of applications. An important and timely question is …

Small molecules that deter the functions of DNA damage response machinery are
postulated to be useful for enhancing the DNA damaging effects of chemotherapy or ionizing …

B-cell lymphoma 6 (BCL6) inhibition is a promising mechanism for treating hematological
cancers but high quality chemical probes are necessary to evaluate its therapeutic potential …

Abstract Cyclin-dependent kinase 12 (CDK12) plays a crucial role in DNA-damage
response gene transcription and has recently been validated as a promising target in cancer …

The rational design of α-helix–mimicking peptidomimetics provides a streamlined approach
to discover potent inhibitors for protein− protein interactions (PPIs). However, designing cell …

Assessment of the interactions between a drug and its protein target in a physiologically
relevant cellular environment constitutes a major challenge in the pre-clinical drug discovery …

Approximately 95% of human genes are alternatively spliced, and aberrant splicing events
can cause disease. One pre-mRNA that is alternatively spliced and linked to …

Sphaeropsidins are iso-pimarane diterpenes produced by phytopathogenic fungi that
display promising anticancer activities. Sphaeropsidin A, in particular, has been shown to …

The bioavailability of small-molecule drugs remains a critical challenge in pharmaceutical
development, significantly impacting therapeutic efficacy and commercial viability. This …

Severe acute respiratory syndrome coronaviruses 1 and 2 (SARS-CoV-1 and SARS-CoV-2)
pose a threat to global public health. The 3C-like main protease (M pro), which presents …