Infrared (IR) spectroscopic imaging records spatially resolved molecular vibrational spectra,
enabling a comprehensive measurement of the chemical makeup and heterogeneity of …

Vibrational spectroscopy and imaging promise molecular information that can be rapidly
acquired without the need for specialized stains or dyes, thereby potentially simplifying and …

Understanding metabolism is indispensable in unraveling the mechanistic basis of many
physiological and pathological processes. However, in situ metabolic imaging tools are still …

Vibrational circular dichroism (VCD) spectroscopy has emerged as a powerful platform to
quantify chirality, a vital biological property that performs a pivotal role in the metabolism of …

Mid-infrared spectroscopy has been applied to research in biology and medicine for more
than 20 years and conceivable applications have been identified. More recently, these …

Advancement of discrete frequency infrared (DFIR) spectroscopic microscopes in image
quality and data throughput are critical to their use for analytical measurements. Here, we …

Anisotropic molecular alignment occurs ubiquitously and often heterogeneously in three
dimensions (3D). However, conventional imaging approaches based on polarization can …

Infrared (IR) spectroscopic imaging instruments' performance can be characterized and
optimized by an analysis of their limit of detection (LOD). Here we report a systematic …

Discrete frequency infrared chemical imaging is transforming the practice of
microspectroscopy by enabling a diversity of instrumentation and new measurement …

Long-wavelength identification of microcalcifications in breast cancer tissue is demonstrated
using a novel upconversion raster scanning microscope. The system consists of quantum …