Antibodies are highly potent therapeutic scaffolds with more than a hundred different
products approved on the market. Successful development of antibody-based drugs …

Amyloid fibrils are supramolecular homopolymers of proteins that play important roles in
biological functions and disease. These objects have received an exponential increase in …

Amyloid-like aggregates of the microtubule-associated protein Tau are associated with
several neurodegenerative disorders including Alzheimer's disease. The existence of …

Fibrillar protein aggregation is a hallmark of a variety of human diseases. Examples include
the deposition of amyloid-β and tau in Alzheimer's disease, and that of α-synuclein in …

While the initial pathology of Parkinson's disease and other α‐synucleinopathies is often
confined to circumscribed brain regions, it can spread and progressively affect adjacent and …

Proteins carry out the vast majority of functions in cells, but can only do so when properly
folded. Following stress or mutation, proteins can lose their proper fold, resulting in …

The amyloid aggregation of alpha-synuclein within the brain is associated with the
pathogenesis of Parkinson's disease (PD) and other related synucleinopathies, including …

Amyloid fibrillar assemblies, originally identified as pathological entities in
neurodegenerative diseases, have been widely adopted by various proteins to fulfill diverse …

Protein amyloid aggregation has been widely observed to occur and plays important roles in
both physiological processes and pathological diseases. Remarkably, amyloid aggregates …

Segments of proteins with high β-strand propensity can self-associate to form amyloid fibrils
implicated in many diseases. We describe a general approach to bind such segments in β …