The central role of glutathione in the pathophysiology of human diseases

R Franco, OJ Schoneveld, A Pappa… - Archives of physiology …, 2007 - Taylor & Francis
Reduced glutathione (L-γ-glutamyl-L-cysteinyl-glycine, GSH) is the prevalent low-molecular-
weight thiol in mammalian cells. It is formed in a two-step enzymatic process including, first …

Physiological and pathological aspects of GSH metabolism

R Njälsson, S Norgren - Acta paediatrica, 2005 - Wiley Online Library
The antioxidant glutathione is found in low levels in diseases in which increasing evidence
implicate oxidative stress in the development of the disease, for example retinopathy of …

Metabolomics analysis identifies glutamic acid and cystine imbalances in COVID-19 patients without comorbid conditions. Implications on redox homeostasis and …

JC Páez-Franco, JL Maravillas-Montero… - PLoS …, 2022 - journals.plos.org
It is well known that the presence of comorbidities and age-related health issues may hide
biochemical and metabolic features triggered by SARS-CoV-2 infection and other diseases …

Neuroimaging findings of organic acidemias and aminoacidopathies

N Reddy, SF Calloni, HJ Vernon, E Boltshauser… - Radiographics, 2018 - pubs.rsna.org
Although individual cases of inherited metabolic disorders are rare, overall they account for
a substantial number of disorders affecting the central nervous system. Organic acidemias …

Controlled growth of gold nanostars: effect of spike length on SERS signal enhancement

SV Sheen Mers, S Umadevi, V Ganesh - ChemPhysChem, 2017 - Wiley Online Library
Two different types of gold nanostars (Au NS), namely, short‐spiked nanostars (SSNS) and
long‐spiked nanostars (LSNS), are prepared by using a hexagonal lyotropic liquid …

Genotype, enzyme activity, glutathione level, and clinical phenotype in patients with glutathione synthetase deficiency

R Njålsson, E Ristoff, K Carlsson, A Winkler, A Larsson… - Human genetics, 2005 - Springer
Glutathione synthetase (GS) deficiency is a rare autosomal recessive disorder. The clinical
phenotype varies widely, and nearly 30 different mutations in the GSS gene have been …

Clinical acid–base pathophysiology: disorders of plasma anion gap

OW Moe, D Fuster - Best Practice & Research Clinical Endocrinology & …, 2003 - Elsevier
The plasma anion gap is a frequently used parameter in the clinical diagnosis of a variety of
conditions. The commonest application of the anion gap is to classify cases of metabolic …

A case of severe glutathione synthetase deficiency with novel GSS mutations

H Xia, J Ye, L Wang, J Zhu, Z He - Brazilian Journal of Medical and …, 2018 - SciELO Brasil
Glutathione synthetase deficiency (GSSD) is a rare inborn error of glutathione metabolism
with autosomal recessive inheritance. The severe form of the disease is characterized by …

Case report: A Chinese patient with glutathione synthetase deficiency and a novel glutathione synthase mutation

X Wu, J Jiao, Y Xia, X Yan, Z Liu, Y Cao, L Ma - Frontiers in Pediatrics, 2023 - frontiersin.org
Glutathione synthetase deficiency (GSSD) is an autosomal-recessive metabolic disorder
caused by glutathione synthetase (GSS) gene mutations. No more than 90 cases of GSSD …

Blood transcriptome analysis: Ferroptosis and potential inflammatory pathways in post-traumatic stress disorder

J Zhu, Y Zhang, R Ren, LD Sanford, X Tang - Frontiers in Psychiatry, 2022 - frontiersin.org
Background Transcriptome-wide analysis of peripheral blood in post-traumatic stress
disorder (PTSD) indicates widespread changes in immune-related pathways and function …