Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …

Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …

Protein lysine acetylation has emerged as a key posttranslational modification in cellular
regulation, in particular through the modification of histones and nuclear transcription …

Chromatin is important for the regulation of transcription and other functions, yet the diversity
of chromatin composition and the distribution along chromosomes are still poorly …

Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet
its regulation is poorly understood. We demonstrated a direct role for histone modifications …

Alternative pre-mRNA splicing is a highly cell type–specific process essential to generating
protein diversity. However, the mechanisms responsible for the establishment and …

Increasing evidence suggests that chromatin modifications have important roles in
modulating constitutive or alternative splicing. Here we demonstrate that the PWWP domain …

Research over the past three decades has firmly established lysine acetyltransferases
(KATs) as central players in regulating transcription. Recent advances in genomic …

In Saccharomyces cerevisiae, cryptic transcription at the coding region is prevented by the
activity of Sin3 histone deacetylase (HDAC) complex Rpd3S, which is carried by the …

Methylation of histone H3 lysine 36 (H3K36) plays crucial roles in the partitioning of
chromatin to distinctive domains and the regulation of a wide range of biological processes …