Cyclic peptides represent invaluable scaffolds in biological affinity, providing diverse
collections for discovering functional molecules targeting challenging biological entities and …

Peptide stapling is a strategy for improving the biological properties of peptides. Herein, we
report a novel method for stapling peptides that utilizes bifunctional triazine moieties for two …

Peptide stapling reactions represent powerful methods for structuring native α-helices to
improve their bioactivity in targeting protein–protein interactions (PPIs). In light of a growing …

Combination of cysteine-containing peptides with electrophiles provides efficient access to
cyclo-organopeptides. However, there are no routes to intrinsically fluorescent cyclo …

Genetically encoded libraries (GEL) are increasingly being used for the discovery of ligands
for “undruggable” targets that cannot be addressed with small molecules. Foundational GEL …

Genetically-encoded libraries (GEL) are increasingly used for discovery of ligands for
'undruggable'targets that cannot be addressed with small molecules. However, there is …