X-ray structure of the human α4β2 nicotinic receptor
Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical
neurotransmission at the neuromuscular junction and have diverse signalling roles in the …
neurotransmission at the neuromuscular junction and have diverse signalling roles in the …
[HTML][HTML] Elephants in the dark: insights and incongruities in pentameric ligand-gated ion channel models
RJ Howard - Journal of Molecular Biology, 2021 - Elsevier
The superfamily of pentameric ligand-gated ion channels (pLGICs) comprises key players in
electrochemical signal transduction across evolution, including historic model systems for …
electrochemical signal transduction across evolution, including historic model systems for …
Structure of the native muscle-type nicotinic receptor and inhibition by snake venom toxins
The nicotinic acetylcholine receptor, a pentameric ligand-gated ion channel, converts the
free energy of binding of the neurotransmitter acetylcholine into opening of its central pore …
free energy of binding of the neurotransmitter acetylcholine into opening of its central pore …
Evolution of pentameric ligand-gated ion channels: Pro-loop receptors
Pentameric ligand-gated ion channels (pLGICs) are ubiquitous neurotransmitter receptors in
Bilateria, with a small number of known prokaryotic homologues. Here we describe a new …
Bilateria, with a small number of known prokaryotic homologues. Here we describe a new …
Allosteric regulation of pentameric ligand-gated ion channels: an emerging mechanistic perspective
Pentameric ligand-gated ion channels (pLGICs) play a central role in intercellular
communications in the nervous system by converting the binding of a chemical messenger …
communications in the nervous system by converting the binding of a chemical messenger …
A predicted binding site for cholesterol on the GABAA receptor
Modulation of the GABA type A receptor (GABA AR) function by cholesterol and other
steroids is documented at the functional level, yet its structural basis is largely unknown …
steroids is documented at the functional level, yet its structural basis is largely unknown …
A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment
J Kaiser, CGW Gertzen, T Bernauer, G Höfner… - Toxicology letters, 2023 - Elsevier
Organophosphorus compounds (OPCs) are highly toxic compounds that can block
acetylcholine esterase (AChE) and thereby indirectly lead to an overstimulation of …
acetylcholine esterase (AChE) and thereby indirectly lead to an overstimulation of …
Chasing the open-state structure of pentameric ligand-gated ion channels
G Gonzalez-Gutierrez, Y Wang, GD Cymes… - Journal of General …, 2017 - rupress.org
Remarkable advances have been made toward the structural characterization of ion
channels in the last two decades. However, the unambiguous assignment of well-defined …
channels in the last two decades. However, the unambiguous assignment of well-defined …
Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography
G Gonzalez-Gutierrez, LG Cuello… - Proceedings of the …, 2013 - National Acad Sciences
Cryoelectron microscopy and X-ray crystallography have recently been used to generate
structural models that likely represent the unliganded closed-channel conformation and the …
structural models that likely represent the unliganded closed-channel conformation and the …
The role of intracellular linkers in gating and desensitization of human pentameric ligand-gated ion channels
It has recently been proposed that post-translational modification of not only the M3–M4
linker but also the M1–M2 linker of pentameric ligand-gated ion channels modulates …
linker but also the M1–M2 linker of pentameric ligand-gated ion channels modulates …