Mast cells (MCs), apart from their classic role in allergy, contribute to a number of biologic
processes including wound healing. In particular, two aspects of their histologic distribution …

Collagen, an extracellular protein, covers the entire human body and has several important
biological functions in normal physiology. Recently, collagen from non-human sources has …

The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors that
are members of the receptor tyrosine kinase family. Both DDRs bind a number of different …

Activated fibroblasts promote physiological wound repair following tissue injury. However,
dysregulation of fibroblast activation contributes to the development of fibrosis by enhanced …

Almost all human cancers display dysregulated expression and/or function of one or more
receptor tyrosine kinases (RTKs). The strong causative association between altered RTK …

Wound treatment remains one of the most prevalent and economically burdensome
healthcare issues in the world. Poly (lactic-co-glycolic acid)(PLGA) supplies lactate that …

The discoidin domain receptors (DDRs) are receptor tyrosine kinases that recognize
collagens as their ligands. DDRs display unique structural features and distinctive activation …

Collagens form the fibrous component of the extracellular matrix in all multi-cellular animals.
Collagen type I is the most abundant collagen present in skin, tendons, vasculature, as well …

Growth factor therapies to induce angiogenesis and thereby enhance the blood perfusion,
hold tremendous potential to address the shortcomings of current impaired wound care …

Tissue injury provokes a series of events containing inflammation, new tissue formation and
tissue remodeling which are regulated by the spatially and temporally coordinated …