The rise of regulatory RNA

KV Morris, JS Mattick - Nature Reviews Genetics, 2014 - nature.com
Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

[HTML][HTML] Next generation sequencing technology: advances and applications

HPJ Buermans, JT Den Dunnen - … Acta (BBA)-Molecular Basis of Disease, 2014 - Elsevier
Impressive progress has been made in the field of Next Generation Sequencing (NGS).
Through advancements in the fields of molecular biology and technical engineering …

[HTML][HTML] Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12

Y Teng, F Xu, X Zhang, J Mu, M Sayed, X Hu, C Lei… - Molecular Therapy, 2021 - cell.com
Lung inflammation is a hallmark of coronavirus disease 2019 (COVID-19). In this study, we
show that mice develop inflamed lung tissue after being administered exosomes released …

RNA sequencing: advances, challenges and opportunities

F Ozsolak, PM Milos - Nature reviews genetics, 2011 - nature.com
In the few years since its initial application, massively parallel cDNA sequencing, or RNA-
seq, has allowed many advances in the characterization and quantification of …

[HTML][HTML] Interplay between MicroRNAs and oxidative stress in neurodegenerative diseases

J Konovalova, D Gerasymchuk, I Parkkinen… - International journal of …, 2019 - mdpi.com
MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal
differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis …

MicroRNAs in human cancer

TA Farazi, JI Hoell, P Morozov, T Tuschl - MicroRNA cancer regulation …, 2013 - Springer
Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20–23-nucleotide (nt)
length that control gene expression in many cellular processes. These molecules typically …

[HTML][HTML] Cortical evolution: judge the brain by its cover

DH Geschwind, P Rakic - Neuron, 2013 - cell.com
To understand the emergence of human higher cognition, we must understand its biological
substrate—the cerebral cortex, which considers itself the crowning achievement of evolution …

Evolution of microRNA diversity and regulation in animals

E Berezikov - Nature Reviews Genetics, 2011 - nature.com
In the past decade, microRNAs (miRNAs) have been uncovered as key regulators of gene
expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic …

转录组研究新技术: RNA-Seq 及其应用

祁云霞, 刘永斌, 荣威恒 - 遗传, 2011 - chinagene.cn
转录组是特定组织或细胞在某一发育阶段或功能状态下转录出来的所有RNA 的集合.
转录组研究能够从整体水平研究基因功能以及基因结构, 揭示特定生物学过程以及疾病发生过程 …

Genetic variation in microRNA networks: the implications for cancer research

BM Ryan, AI Robles, CC Harris - Nature reviews cancer, 2010 - nature.com
Many studies have highlighted the role that microRNAs have in physiological processes and
how their deregulation can lead to cancer. More recently, it has been proposed that the …